Raquel Araujo Legido

LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype

Nadia Cobo‐Vuilleumier, Silvia Rodríguez-Fernández, Livia López–Noriega, Petra I. Lorenzo et autres

Abstract Background The complex aetiology of type 1 diabetes (T1D), characterised by a detrimental cross‐talk between the immune system and insulin‐producing beta cells, has hindered the development of effective disease‐modifying therapies. The discovery that the pharmacological activation of LRH‐1/NR5A2 can reverse hyperglycaemia …

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LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

Nadia Cobo‐Vuilleumier, Silvia Rodríguez-Fernández, Livia López–Noriega, Petra I. Lorenzo et autres

ABSTRACT The intricate etiology of type 1 diabetes mellitus (T1D), marked by a detrimental cross-talk between the immune system and insulin-producing β-cells, has impeded effective disease-modifying therapies. The discovery that pharmacological activation of the nuclear receptor LRH-1/NR5A2 can reverse hyperglycemia in mouse …

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The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent

Naroa Goikoetxea‐Usandizaga, Miren Bravo, Leire Egia‐Mendikute, Leticia Abecia et autres

BACKGROUND AND AIMS: Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative …

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NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function

Eugenia Martin Vázquez, Nadia Cobo‐Vuilleumier, Raquel Araujo Legido, Sandra Marín‐Cañas et autres

LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling revealed that the expression of PTGS2/COX2 is increased by BL001. Herein, …

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LRH-1/NR5A2 regulates the PTGS2-PGE 2 -PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001

Eugenia Martin Vázquez, Nadia Cobo‐Vuilleumier, Raquel Araujo Legido, Emanuele M. Nola et autres

ABSTRACT We have previously described a role of LRH-1/NR5A2 in islet morphogenesis during postnatal development and reported that the treatment with BL001, an agonist of LRH-1/NR5A2, protects islets against-stress induced apoptosis and reverts hyperglycemia in 3 mouse models of Type 1 Diabetes …

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GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells

Laura Villamayor, Elisa Rodríguez‐Seguel, Raquel Araujo Legido, Manuel Carrasco et autres

GATA4 and GATA6 play essential, but redundant, roles in pancreas formation in mice, and GATA6 mutations cause pancreatic agenesis in humans. GATA6 mutations have also recently been linked to adult-onset diabetes, with subclinical or no exocrine insufficiency, suggesting an important role for …

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Empleo de mutaciones activadoras de la proteína glucoquinasa en la terapia génica-celular de la diabetes Mellitus

Raquel Araujo Legido

Trabajo de Investigacion para optar al grado de Doctor por la Universidad Pablo de Olavide de Sevilla, Departamento de Biologia Molecular e Ingenieria Bioquimica.

Función del factor de transcripción GATA6 en la célula beta pancreática

Anabel Rojas, Laura Villamayor Coronado, Raquel Araujo Legido, Bernat Soria Escoms et autres

Resumen del trabajo presentado al XXVIII Congreso Nacional de la Sociedad Española de diabetes, celebrado en Bilbao del 20 al 22 de abril de 2016.

L-Type Ca2+ Channels and SK Channels in Mouse Embryonic Stem Cells and Their Contribution to Cell Proliferation

J.M. Vegara-Meseguer, Horacio Pérez‐Sánchez, Raquel Araujo Legido, Franz Martı́n et autres

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Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells

Pilar Vaca, Genoveva Berná, Raquel Araujo Legido, Everardo M. Carneiro et autres

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