Thomas N. Ferraro

Potential regulation of kynurenine pathway metabolism by the galantamine–memantine combination in rheumatologic diseases: A hypothesis-driven review

Navya Mathew, Sebin George, Patricia Rejimon, Craig Orofino et autres

in, us, au, gb (code pays fourni par la source)

USP25 in genetic generalized epilepsy: a gene under scrutiny

Maryam Erfanian Omidvar, Jill R. Murrell, Anna J. Prentice, Ingo Helbig et autres

Maryam Erfanian Omidvar, Jill R Murrell, Anna J Prentice, Ingo Helbig, Holger Lerche, Patrick May, Epi25 Collaborative , Siwei Chen, Zaid Afawi, Quratulain

lu, de, us (code pays fourni par la source)

Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain

Adam P. Berg, Carlos C. Flores, Micah Lefton, Yuji Owada et autres

Background/Objectives: Patients with epilepsy commonly experience patterns of seizures that change with sleep/wake behavior or diurnal rhythms. The cellular and molecular mechanisms that underlie these patterns in seizure activity are not well understood but may involve non-neuronal cells, such as astrocytes. Our …

us, jp (code pays fourni par la source)

Memantine for the Treatment of Primary Negative Symptoms in Schizophrenia: A Meta-analysis of Randomized Controlled Trials

Houlin Hong, Jack Donlon, Martin Schaefer, Susanne Sarkar et autres

us, de, ch, cl, nl, gb (code pays fourni par la source)

Astrocyte Fabp7 modulates nocturnal seizure threshold and activity-dependent gene expression in mouse brain

Micah Lefton, Carlos C. Flores, Yuji Owada, Christopher J. Davis et autres

Abstract Epileptic seizures often track with time of day and/or changes in vigilance state; however, specific molecular and cellular mechanisms driving the ictal and temporal associations are lacking. Astrocytes are a type of glial cell known to modulate neuronal excitability and circadian …

us, jp (code pays fourni par la source)

Modulation of mu-opioid receptor function alters electroshock seizure responses in mice

Thomas N. Ferraro, James DeChiara, Ruoyu Chen, Yong Chen et autres

We studied the effects of mu-opioid receptor (MOR) modulation on seizure responses to electroshock stimulation in C57BL/6J (B6) and DBA/2J (D2) mice of both sexes. Using a genetic approach, we show that B6 and D2 mice with a constitutive deletion of the …

us (code pays fourni par la source)

Enhancing Single-Cell and Bulk Hi-C Data Using a Generative Transformer Model

Thomas N. Ferraro, Liang Chen, Shaoqiang Zhang, Yong Chen

The 3D organization of chromatin in the nucleus plays a critical role in regulating gene expression and maintaining cellular functions in eukaryotic cells. High-throughput chromosome conformation capture (Hi-C) and its derivative technologies have been developed to map genome-wide chromatin interactions at the …

cn, us (code pays fourni par la source)

The astrocyte Fabp7 gene regulates diurnal seizure threshold and activity-dependent gene expression in mice

Micah Lefton, Carlos C. Flores, Yuji Owada, Christopher J. Davis et autres

Abstract Epileptic seizures are often influenced by time-of-day and changes in vigilance state, yet the molecular and cellular mechanisms underpinning these associations remain poorly understood. Astrocytes, a pivotal type of glial cell, play a critical role in modulating neuronal excitability and circadian …

us, jp (code pays fourni par la source)

Galantamine-Memantine Combination in the Treatment of Parkinson’s Disease Dementia

Emma D. Frost, Vishnu Byroju, Jamir Pitton Rissardo, Jack Donlon et autres

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects over 1% of population over age 60. It is defined by motor and nonmotor symptoms including a spectrum of cognitive impairments known as Parkinson's disease dementia (PDD). Currently, the only US Food …

us, cl, au, gb (code pays fourni par la source)

Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

Siwei Chen, Bassel Abou‐Khalil, Zaid Afawi, Quratulain Zulfiqar Ali et autres

us, il, ca, it, au, gb, tr, ag, fr, hk, de, lb, ps, ie, tw, fi, be, nz, lu, at (code pays fourni par la source)

F94. FENTANYL AND XYLAZINE POLYSUBSTANCE EXPOSURE INDUCES SHARED AND DIVERGENT ISOFORM- AND SEX-SPECIFIC ALTERATIONS IN THE NUCLEUS ACCUMBENS TRANSCRIPTOME

Samar Nasser Chehimi, Richard C. Crist, R. Merkel, Thomas N. Ferraro et autres

us (code pays fourni par la source)

W31. KETAMINE AND ELECTROCONVULSIVE THERAPY DEPRESSION TREATMENTS ALTER ISOFORM- AND CELL TYPE-SPECIFIC TRANSCRIPTOMES IN THE MOUSE PREFRONTAL FRONTAL CORTEX

Samar Nasser Chehimi, Richard C. Crist, Alexander I. Batterman, Aela A. Williams et autres

us (code pays fourni par la source)