Accès ouvert
2025
article
OpenAlex
Adam P. Berg, Carlos C. Flores, Micah Lefton, Yuji Owada et autres
Background/Objectives: Patients with epilepsy commonly experience patterns of seizures that change with sleep/wake behavior or diurnal rhythms. The cellular and molecular mechanisms that underlie these patterns in seizure activity are not well understood but may involve non-neuronal cells, such as astrocytes. Our …
us, jp
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Accès ouvert
2025
article
OpenAlex
Micah Lefton, Carlos C. Flores, Yuji Owada, Christopher J. Davis et autres
Abstract Epileptic seizures often track with time of day and/or changes in vigilance state; however, specific molecular and cellular mechanisms driving the ictal and temporal associations are lacking. Astrocytes are a type of glial cell known to modulate neuronal excitability and circadian …
us, jp
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Accès ouvert
2025
preprint
OpenAlex
Micah Lefton, Carlos C. Flores, Yuji Owada, Christopher J. Davis et autres
Abstract Epileptic seizures are often influenced by time-of-day and changes in vigilance state, yet the molecular and cellular mechanisms underpinning these associations remain poorly understood. Astrocytes, a pivotal type of glial cell, play a critical role in modulating neuronal excitability and circadian …
us, jp
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Accès ouvert
2024
article
OpenAlex
Yool Lee, Carlos C. Flores, Micah Lefton, Sukanya Bhoumik et autres
Fatty acid binding protein 7 (FABP7) is a multifunctional chaperone involved in lipid metabolism and signaling. It is primarily expressed in astrocytes and neural stem cells (NSCs), as well as their derived malignant glioma cells within the central nervous system. Despite growing …
us, jp
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Accès ouvert
2023
article
OpenAlex
Jason R. Gerstner, Carlos C. Flores, Micah Lefton, Brooke Rogers et autres
Sleep and circadian rhythms are observed broadly throughout animal phyla and influence neural plasticity and cognitive function. However, the few phylogenetically conserved cellular and molecular pathways that are implicated in these processes are largely focused on neuronal cells. Research on these topics …
us
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Accès ouvert
2022
article
OpenAlex
William M. Vanderheyden, Micah Lefton, Carlos C. Flores, Yuji Owada et autres
Humans with post-traumatic stress disorder (PTSD) exhibit sleep disturbances that include insomnia, nightmares, and enhanced daytime sleepiness. Sleep disturbances are considered a hallmark feature of PTSD; however, little is known about the cellular and molecular mechanisms regulating trauma-induced sleep disorders. Using a …
us, jp
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