Jonathan Howard

Agreement between seroprevalence- and model-based estimates of COVID-19 burden

Nana Owusu‐Boaitey, Lucas Böttcher, Gideon Meyerowitz‐Katz, Jonathan Howard et autres

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused significant global harm. Seroprevalence studies detected antibody increases from SARS-CoV-2 infection, assessing transmission and risk from infection. These studies and epidemiological modeling informed public health policy and behavior. Biases in early seroprevalence …

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Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano et autres

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B-PwMS) experience a more severe disease course than non-Hispanic White people with MS (NHW-PwMS). Here we investigated structural and functional connectivity as well as structure-function …

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In vivo acoustoelectric neural recording in mice enabled by ultrasound-induced frequency mixing

Jean L. Rintoul, Jonathan Howard, Patrycja Dzialecka, Xiaoqi Zhu et autres

There is a long-standing need in neuroscience for non-invasive methods that can record neural electrical activity with focal precision to diagnose brain disorders and interrogate circuit function. Here, we introduce acoustoelectric neural recording, which exploits ultrasound-induced frequency mixing to recover electrophysiological signals …

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Black and Non-Hispanic White persons with multiple sclerosis: Social determinants of health and health inequities

Marta Ponzano, Nicole Graziano, Claire Wigley, Giacomo Boffa et autres

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Natalizumab and fumarate treatment differentially modulate CD4+ T cell and B cell subtypes in multiple sclerosis patients without impacting durable COVID-19 vaccine responses

Ryan Curtin, Yogambigai Velmurugu, Fatoumatta Dibba, Hao Yuan et autres

Background: There is a greater risk of complications from severe COVID-19 in immunocompromised patients with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs), as well as a diminished vaccine response. Methods: In this exploratory, observational study, we recruited 28 patients with …

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Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Jonathan Raihan Abbas et autres

BACKGROUND: Molnupiravir and nirmatrelvir-ritonavir are oral antivirals that have shown efficacy in preventing disease progression in outpatients with COVID-19. We aimed to evaluate these treatments for patients hospitalised with COVID-19 pneumonia, for whom data on these antivirals are scarce. METHODS: The RECOVERY …

Confabulation as a Presenting Symptom of Bilateral Thalamic Venous Congestion in the Setting of Arteriovenous Fistula (P1-14.003)

Catherine Imossi, Hannah Kopinsky, Philip Kuball, Jonathan Howard

NA

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Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Jaffar Abbas et autres

Background: Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not receiving ventilatory support (the combination of non-invasive …

6953 Bridging the Gender Gap: Sexually Dimorphic Brain Responses in Distressing Low Sexual Desire

Jovanna Tsoutsouki, Natalie Ertl, Edouard Mills, Meaghan Wall et autres

Abstract Disclosure: J. Tsoutsouki: None. N. Ertl: None. E.G. Mills: None. M.B. Wall: None. L. Thurston: None. L. Yang: None. S. Suladze: None. T. Hunjan: None. M. Phylactou: None. B. Patel: None. J. Howard: None. A. Abbara: None. D. Golmeier: None. A.N. …

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The neural bases underlying distressing low sexual desire is sex specific

Jovanna Tsoutsouki, Natalie Ertl, Edouard Mills, Matthew B. Wall et autres

Impact of cross-reactivity and herd immunity on SARS-CoV-2 pandemic severity

Nana Owusu‐Boaitey, Lucas Böttcher, Daihai He, Ryenchindorj Erkhembayar et autres

Public health systems reported low mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in East Asia, in low-income countries, and for children during the first year of the SARS-CoV-2 pandemic. These reports led commentators to suggest that cross-reactive immunity from prior …

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Women and men with distressing low sexual desire exhibit sexually dimorphic brain processing

Natalie Ertl, Edouard Mills, Matthew B. Wall, Layla Thurston et autres

Distressing low sexual desire, termed Hypoactive Sexual Desire Disorder (HSDD), affects approximately 10% of women and 8% of men. In women, the 'top-down' theory of HSDD describes hyperactivity in higher-level cognitive brain regions, suppressing lower-level emotional/sexual brain areas. However, it is unknown …

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