Caroline M. Milner

Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism

Caroline E. Kratka, Ruixu Huang, Jeffrey Pea, Robin M. Skory et autres

Cumulus cells have well-established roles early in ovulation but the key molecules that drive their behavior in later stages, leading to follicle rupture, remain underexplored. Here, we observed that inhibition of proprotein convertases (PCSKs) via a pan-inhibitor (PCI) impaired follicular rupture and …

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Evidence of an allostatic response by intestinal tissues following induction of joint inflammation

Meghan M. Moran, Jun Li, Quan Shen, Sheona P. Drummond et autres

Disrupted intestinal epithelial barrier function has been proposed to be integral to rheumatoid arthritis (RA) progression and pathogenesis. To further define the molecular pathways in synovial inflammation and the response of the intestinal tissues, we have used a rat model of mono-joint …

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Evidence of an Allostatic Response by Intestinal Tissues Following Induction of Joint Inflammation

Meghan M. Moran, Jun Li, Quan Shen, Sheona P. Drummond et autres

ABSTRACT Disrupted intestinal epithelial barrier function has been proposed to be integral to rheumatoid arthritis (RA) progression and pathogenesis. To further define the molecular pathways in synovial inflammation and the response of the intestinal tissues, we have used a rat model of …

us, gb (code pays fourni par la source)

Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan–hyaladherin interactions

Rebecca J. Dodd, Charles D. Blundell, Benedict M. Sattelle, Jan J. Enghild et autres

The glycosaminoglycan hyaluronan (HA) is a ubiquitous, nonsulfated polysaccharide with diverse biological roles mediated through its interactions with HA-binding proteins (HABPs). Most HABPs belong to the Link module superfamily, including the major HA receptor, CD44, and secreted protein TSG-6, which catalyzes the …

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A novel method to quantify TSG‐6 protein levels in synovial fluid from osteoarthritis patients

Jenny L. Scott, Yan Dong, Junying Yin, Rebecca J. Dodd et autres

Abstract TSG‐6, the protein product of Tumor Necrosis Factor‐stimulated gene‐6, is a potential biomarker of disease activity/progression in osteoarthritis (OA). By ELISA, TSG‐6 is elevated in synovial fluid (SF) from OA patients and its catalytic activity, for the covalent transfer of inter‐α‐inhibitor …

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170 NEW METHOD FOR QUANTIFICATION OF TSG-6 IN SYNOVIAL FLUID OF OSTEOARTHRITIS PATIENTS

Jenny L. Scott, Yan Dong, Jungying Yin, Rebecca J. Dodd et autres

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Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan- hyaladherin interactions

Rebecca J. Dodd, Charles D. Blundell, Benedict M. Sattelle, Jan J. Enghild et autres

Abstract The glycosaminoglycan hyaluronan (HA) is a ubiquitous, non-sulphated polysaccharide with diverse biological roles mediated through its interactions with HA-binding proteins (HABPs). Most HABPs belong to the Link module superfamily, including the major HA receptor, CD44, and secreted protein TSG-6, which catalyzes …

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Familial lymphoblastic leukemia: a case of germline rearrangement?

N Scibelli, J. J. Wert, Caroline M. Milner

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Inter-alpha-trypsin inhibitor (IαI) and hyaluronan modifications enhance the innate immune response to influenza virus in the lung

Fengying Tang, Stephen R. Reeves, Jourdan E. Brune, Mary Y. Chang et autres

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The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: A potential disease-modifying OA drug

Sheona P. Drummond, Eckart Bartnik, Nikolaos Kouvatsos, Jenny L. Scott et autres

OBJECTIVE: To investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA. DESIGN: Knee articular cartilages from OA patients were analyzed for TSG-6 protein …

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The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease

Joo Youn Oh, Jin Suk Ryu, Hyeon Ji Kim, Nikolaos Kouvatsos et autres

PURPOSE: To investigate the potential of the Link_TSG6 polypeptide comprising the Link module of human TSG-6 (TNF-stimulated gene/protein-6) as a novel treatment for dry eye disease (DED). METHODS: mouse model and the desiccating stress model. The effects of Link_TSG6 on the ocular …

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The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug

Sheona P. Drummond, Eckart Bartnik, Nikolaos Kouvatsos, Jenny L. Scott et autres

ABSTRACT Objectives To investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA. Methods Knee articular cartilages from OA patients were analysed for TSG-6 …

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