Jan J. Enghild

Abdominal-B regulates the male seminal fluid transferome and new fecundity factors required for sperm sex peptide binding

Kathrin Steck, Lina Verbakel, Peter Kerwin, Vladimir Trajanovikj et autres

Seminal fluid proteins determine reproductive success in a wide range of animals. In the Drosophila male accessory gland, seminal fluid is mainly produced by two cell types, a majority of main cells and a small number of secondary cells that possess a …

ch, dk (code pays fourni par la source)

FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster

Kasper Grønbjerg Winther, Juliette Schneider, Gabrielle Haas, Anna Hvarregaard Christensen et autres

STING is an evolutionarily conserved key regulator of innate immunity. In the model organism Drosophila melanogaster, STING activates the NF-κB-like transcription factor Relish, initially characterized for its role in the antibacterial IMD pathway. The versatile FADD/Caspase-8 axis is widely used in various …

fr, dk, cn, us (code pays fourni par la source)

Antagonist nanobodies prevent protease inhibition by CD109

Kathrine Tejlgård Jensen, Ana Viana Almeida, Sanne Rönning, Maximillian Karlander et autres

Cluster of differentiation 109 (CD109) is a cell surface protein found on many human cell types, including keratinocytes, platelets, and T-cells. It is a protease inhibitor of the α-macroglobulin protein superfamily and is reported to affect signaling pathways such as TGFβ and …

dk, se (code pays fourni par la source)

Abdominal-B regulates the male seminal fluid transferome and new female fecundity factors required for sperm sex peptide binding

Kathrin Steck, Lina Verbakel, Peter Kerwin, Vladimir Trajanovikj et autres

Abstract Seminal fluid proteins determine reproductive success in a wide range of animals. In the Drosophila male accessory gland, seminal fluid is mainly produced by two cell types, a vast majority of main cells and a small number of secondary cells that …

ch, dk (code pays fourni par la source)

Homologous HipA ‐like kinases are controlled by internal translational initiation and genetic organisation

Adriana Chrenková, Payal Nashier, Cecilie L. Madsen, Janni Nielsen et autres

HipA‐like kinases are widespread bacterial serine–threonine kinases, yet their regulatory mechanisms remain poorly understood. Here, we characterise two novel HipA‐like systems, the monocistronic hipL and bicistronic hipIN , also encoding HipS‐like and HIRAN domains. We show that the hipL gene contains an …

dk, de (code pays fourni par la source)

Periodontopathogens degrade angiotensin I from the human renin–angiotensin system through surface-attached proteases

Irena Waligórska, Krzysztof M. Żak, Natalia Mikrut, Joanna Budziaszek et autres

The renin-angiotensin system (RAS) has its effects through biologically-active peptides, the angiotensins (Ang). The angiotensinogen-derived precursor, Ang I, is cleaved either to proinflammatory Ang II, which increases blood pressure or to Ang 1-7, which has opposite effects to Ang II. Here, we …

pl, dk, us (code pays fourni par la source)

Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers

Andrew McLain, Suzanne R. Saffie-Siebert, Nadia Sukusu Nielsen, Benjamin Patterson et autres

Proven in vivo efficacy is a key requirement for novel gene therapies proceeding to clinical trial. No gene therapies for corneal dystrophies have been able to progress into patient-led studies due to a lack of suitable animal models expressing a disease phenotype …

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Author response for "Homologous HipA-like kinases are controlled by internal translational initiation and genetic organisation"

Adriana Chrenková, Payal Nashier, Cecilie L. Madsen, Janni Nielsen et autres

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota

Augustinas Silale, Mariusz Madej, Katarzyna Mikruta, Andrew Michael Frey et autres

The Gram-negative β-barrel assembly machinery (BAM) complex catalyses the folding and membrane insertion of newly synthesized β-barrel outer membrane proteins. The BAM is structurally conserved, but most studies have focused on Gammaproteobacteria. Here, using single-particle cryogenic electron microscopy, quantitative proteomics and functional …

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Innocent until proven guilty: Tannerella forsythia may attenuate the virulence of Porphyromonas gingivalis

Mirosław Książęk, Małgorzata Benedyk, Danuta Mizgalska, Irena Waligórska et autres

ABSTRACT Periodontitis is caused by a dysbiotic microbiome beneath the gum line, primarily driven by the major pathobionts Porphyromonas gingivalis ( Pg ) and Tannerella forsythia ( Tf ). Their virulence depends on the excessive, uncontrolled activity of secreted proteases that sustain …

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Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition

Ana V. Almeida, Kathrine Tejlgård Jensen, Seandean L. Harwood, Martin Høgholm Jørgensen et autres

CD109 is a glycosylphosphatidylinositol-anchored protein. In addition to regulating transforming growth factor β (TGF-β) network signaling, CD109 is also a protease inhibitor. Protease cleavage of its bait region triggers a conformational change releasing the major fragment from the cell surface, exposing a …

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TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery

Andrew McLain, Amanda M. Kowalczyk, Paulina Rachwalska, Flavia Maria Sutera et autres

gb, dk, it (code pays fourni par la source)