Taian Liu

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu et autres

Striatal medium spiny neurons expressing D1 dopamine receptors (D1-MSNs) are a key component in the direct pathway of the basal ganglia and exhibit chronically suppressed activity in Parkinson's disease. To enable selective anatomical and functional interrogation of D1-MSNs, we developed an adeno-associated …

cn, mo (code pays fourni par la source)

A neurotensin circuit in the preoptic nucleus mediates progesterone-dependent ovulation

Hong Wang, Lanxiang Li, Robert Naumann, l zhi wei et autres

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A hypothalamic VMPO-supraoptic vasopressin circuit mediates procalcitonin-induced fluid imbalance

Wei Lin, Tingjun Liu, Jinfeng Huang, Lanxiang Li et autres

Sepsis is a life-threatening condition characterized by infection-induced organ dysfunction, with fluid imbalance and cardiovascular instability as cardinal features. Although circulating procalcitonin (PCT) is widely used as a diagnostic and prognostic marker in sepsis, its pathophysiological role remains poorly understood. Here, we …

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Paradoxical role of the mesocorticolimbic Netrin1-DCC pathway in social competition and vulnerability to methamphetamine abuse during adolescence

Wei Xu, Jiafeng Zhong, Lijie Ding, Haiyang Jing et autres

cn (code pays fourni par la source)

Target-stabilized base editors enable robust high-fidelity RNA editing

Taian Liu, Yunping Lin, Qiwei Liu, Wenhui Liao et autres

RNA base editing using engineered deaminases represents a powerful tool to correct mutations at the RNA level. However, widespread off-target effects, primarily arising from dissociated free deaminases, remain a significant challenge. Here, we devise the RECODE (RNA editing with conditionally stable and …

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AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

Jianbang Lin, Yunping Lin, Nana Liu, Wenhua Cao et autres

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Stability Analysis and Treatment of Pebble Soil Slopes Under Rainfall and Earthquake Conditions

Taian Liu, Y. Li

In many mountainous areas of China, frequent geological disasters pose a serious threat to human life and property. The Luding “9.5” earthquake triggered a large number of landslide disasters, causing serious loss of life and property. Therefore, it is extremely urgent to …

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Target-Stabilized Base Editors Enable Robust High-Fidelity RNA Editing

Taian Liu, Yunping Lin, Qiwei Liu, Wenhui Liao et autres

Abstract RNA base editing using engineered deaminases expands target compatibility, offering a powerful tool to correct mutations at the RNA level. However, widespread off-target effects, primarily arising from dissociated free deaminases, remain a significant challenge. Here, we devised the RECODE ( R …

cn (code pays fourni par la source)

A humanized Gs-coupled DREADD for circuit and behavior modulation

Qi Zhang, Ruiqi Wang, Liang Zhang, Mengqi Li et autres

Designer receptors exclusively activated by designer drugs (DREADDs) play important roles in neuroscience research and show great promise for future clinical interventions in neurological diseases. The Gs-coupled DREADD, rM3Ds, modulates excitability in neuron subsets that are sensitive to downstream effectors of Gs …

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Protocol for chemogenetic activation of basal ganglia D1-MSNs and behavioral assessments in a primate Parkinson’s disease model

Yefei Chen, Zexuan Hong, Ting Yan, Yuyuan Zhu et autres

-expressing medium spiny neurons by retrograde adeno-associated virus (AAV) transduction and chemogenetic activation using a designer toolkit. We describe steps for AAV injections and PD primate model induction. We then detail behavioral measurements to assess the therapeutic efficacy of the therapy for …

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Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy

Jianbang Lin, Jing Liu, Qi Zhang, Taian Liu et autres

Abstract Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability is frequently observed with TLE, presumably caused by impaired inhibition of local excitatory neurons. Here, we evaluated the effectiveness of silencing subicular pyramidal neurons to treat a …

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Circuit-specific gene therapy reverses core symptoms in a primate Parkinson’s disease model

Yefei Chen, Zexuan Hong, Jingyi Wang, Kunlin Liu et autres

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