Beatrice Engelmann

Molecular perturbations of Daphnia magna in response to glyphosate – In laboratory medium and river water

Izabela Antepowicz, Beatrice Engelmann, Martin Krauß, Ulrike Rolle-Kampczyk et autres

Among the various emerging contaminants, glyphosate, a widely used active ingredient in herbicidal formulations, has become a pollutant of particular concern. Conventional water monitoring methods fall short in providing insights regarding the underlying toxicity mechanism of glyphosate. To bridge this gap, New …

ie, de (code pays fourni par la source)

Functional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator

Scott Frendo‐Cumbo, Danae Zareifi, Joëlle Bigay, Ana Rita Dias Araújo et autres

Insulin-driven gene regulation is central to adipocyte function, but the roles of many of these genes in lipid metabolism remain unclear. Here, we integrate three transcriptomic datasets to identify insulin-responsive genes and define their functions in human adipocytes using a multiparametric lipid …

dk, se, fr, de, es (code pays fourni par la source)

Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin

Chloe Wray, Victor Castañeda-Monsalve, Beatrice Engelmann, Ulrike Rolle‐Kampczyk et autres

The gut microbiome is essential for neurodevelopment via bidirectional gut-brain axis signaling, yet environmental chemicals can potentially disrupt this communication by altering community structure and xenobiotic metabolism. In this study, we investigated whether the fungicide azoxystrobin, a known metabolic disruptor, modulates microbiome …

de, gb (code pays fourni par la source)

Dataset for Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin

Chloe Wray, Victor Castañeda-Monsalve, Beatrice Engelmann, Ulrike Rolle-Kampczyk et autres

This repository contains datasets and accompanying code underlying figures in Wray & Castañeda-Monsalve et al. It includes zebrafish behavior data, targeted metabolomics datasets, and processed outputs from the simplified human intestinal microbiota (SIHUMIx) model, covering community composition, functional pathway profiles, and untargeted …

de, gb (code pays fourni par la source)

Bempedoic acid directly binds and activates PPARα

Christina Papa, Alina Rose, Hugo N.G. Martin, Abibe Useini et autres

Bempedoic acid (BA) is a recently approved drug that lowers cholesterol and hepatic lipids, yet its mechanism of action remains incompletely understood. Here, we combine transcriptomic, biochemical, and structural approaches to show that BA directly binds to and activates peroxisome proliferator-activated receptor …

de (code pays fourni par la source)

Antibiotics Induce Metabolic and Physiological Responses in Daphnia magna

Katie O’Rourke, Izabela Antepowicz, Beatrice Engelmann, Ulrike Rolle‐Kampczyk et autres

Antibiotics represent a unique and diverse group of drugs, which are known to exert deleterious effects on non-target species and contribute to the phenomenon of antimicrobial resistance. With central inclusion on the EU Surface Water Watch List, and reported known affects in …

ie, de (code pays fourni par la source)

Etablierung von Metabolomik und (Meta)Proteomik zur Analyse der altersabhängigen Entwicklung des Metaboloms im Darm der Honigbiene und der Verwertung von Protein

Martin von Bergen�, Beatrice Engelmann, Mikala Robers, Abdulrahim T. Alkassab et autres

Exposition von Pflanzenschutzmitteln beeinflusst das Verhalten und die Funktionen von Darm und Gehirn bei Honigbienenarbeiterinnen (Apis mellifera)

Cassandra Uthoff, Beatrice Engelmann, Abdulrahim T. Alkassab, Ulrike Rolle-Kampczyk et autres

Plant Protection Product Exposure Affects Honeybee (Apis mellifera) Behaviour, Gut and Brain

Cassandra Uthoff, Beatrice Engelmann, Abdulrahim Alkassab, Ulrike Rolle-Kampcyzk et autres

13C metabolic tracing in human SGBS cells provides a potential new approach methodology for assessing metabolism-disrupting properties of environmental chemicals

Cornelius Goerdeler, Beatrice Engelmann, Helen Broghammer, Alix Sarah Aldehoff et autres

Human exposure to certain environmental chemicals, including phthalates, is linked to metabolic disruption and may thereby contribute to diseases like obesity. However, regulatory methods to evaluate such effects are lacking. DINCH was introduced as a substitute for banned phthalate plasticizers, but its …

de (code pays fourni par la source)

Cross-taxa sublethal impacts of plant protection products on honeybee in-hive and zebrafish swimming behaviours at environmentally relevant concentrations

Cassandra Uthoff, N. Herold, Abdulrahim T. Alkassab, Beatrice Engelmann et autres

Single and mixture exposure to plant protection products (PPPs) can affect non-target organisms at sublethal concentrations, yet the ecological relevance of behavioural effects remains underexplored. Behavioural disruptions can compromise survival and fitness, with exposure occurring across terrestrial and aquatic ecosystems. Here, we …

de (code pays fourni par la source)

Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches

Cassandra Uthoff, Yelyzaveta Yakovlyeva, Beatrice Engelmann, Ulrike Rolle‐Kampczyk et autres

INTRODUCTION: In honey bees, division of labour is a key feature, with age-related behavioural transitions being closely associated with molecular changes in the brain, gut, and microbiota. Despite evidence of both microbiome and brain changes in honey bees, most studies focus on …

de (code pays fourni par la source)