Antibiotics Induce Metabolic and Physiological Responses in Daphnia magna
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Le résumé fourni par la source
Antibiotics represent a unique and diverse group of drugs, which are known to exert deleterious effects on non-target species and contribute to the phenomenon of antimicrobial resistance. With central inclusion on the EU Surface Water Watch List, and reported known affects in multiple model organisms, the importance of the sufficient monitoring of antibiotics in the aquatic environment has been highlighted. Most studies report the impact of individual antibiotics following exposure for a single generation in animals. In this study, we assessed the impact of four antibiotics with different modes of action (amoxicillin, trimethoprim, erythromycin, and sulfamethoxazole) and their mixture on the sentinel species Daphnia magna over three generations, via biochemical markers and a targeted metabolomic analysis of central metabolic pathways. No mortality was observed at 50 mg/L of each selected antibiotic and their composite mixture. Thus, a working concentration of 1 mg/L was chosen to progress this study. Results indicated that enzyme activity was particularly sensitive to exposure to amoxicillin and the mixture, whereas trimethoprim and the mixture induced the most metabolic changes in glycolysis and the TCA cycle. Additionally, the quaternary mixture had a stronger impact on the first generation of daphnids, altering the activity of β-galactosidase, glutathione S-transferase, and acid and alkaline phosphatase, suggesting that Daphnia can adapt to stress caused by antibiotics.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Antibiotics Induce Metabolic and Physiological Responses in Daphnia magna
- Date Crossref
- 20/01/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dublin City University Life Sciences Institute pays non établi dans la noticeUniversité ou école supérieure
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Helmholtz Centre for Environmental Research Department of Molecular Toxicology pays non établi dans la noticeStructure de recherche
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German Centre for Integrative Biodiversity Research pays non établi dans la noticeStructure de recherche
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Leipzig University Institute of Biochemistry pays non établi dans la noticeUniversité ou école supérieure
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School of Biotechnology pays non établi dans la noticeUniversité ou école supérieure
Life Sciences Institute — Dublin City University, Department of Molecular Toxicology — Helmholtz Centre for Environmental Research et German Centre for Integrative Biodiversity Research, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.