Cleber Wanderlei Liria

Development of a Potent and Functional In Vivo Peptide Competitive Inhibitor for the Toxin MazF

Luis R. Pizzolato-Cezar, Phelipe Augusto Mariano Vitale, Cleber Wanderlei Liria, Mario A. R. Pineda et autres

Abstract Cell growth regulation granted by toxin–antitoxin systems enables bacteria to fight phage infections, evade host immune defenses, and survive antibiotic treatment. In this work, a potent and specific peptide competitive inhibitor for the Escherichia coli toxin MazF was developed and named …

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Peptides of Biotechnological Interest: General Concepts, Production, Purification and Chemical Characterization

Kamila de Sousa Gomes, Cleber Wanderlei Liria

Peptides are macromolecules composed of two (dipeptides), 10 (decapeptides) or dozens of amino acid residues (oligopeptides) linked by amide bonds mainly involving α-carbonyl and α-amine groups (peptide bonds). The amino acids are in the L (or S) configuration, but some natural peptides …

Position matters in ester thiolysis by cysteine-containing peptides in micelles and vesicles

Caroline Dutra Lacerda, María A. Juliano, Cleber Wanderlei Liria, Peter Park et autres

Hypothesis The interaction of peptides with nanoaggregates is an active research topic. Cysteine (Cys)-containing peptides open opportunities for developing low molecular weight compounds with interesting properties and potential applications. Knowledge of the relationship between the position of the Cys in the peptides …

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Conjugates of desferrioxamine and aromatic amines improve markers of iron-dependent neurotoxicity

Rodrigo Rodrigues Victor de Carvalho, Tanara Vieira Peres, Cleber Wanderlei Liria, Michael Aschner et autres

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Fundamentos para produção, purificação e caracterização de peptídeos de interesse biotecnológico

Maria Terêsa Machini de Miranda, Cleber Wanderlei Liria

5-Hydroxymethylfurfural and Furfural Base-Free Oxidation over AuPd Embedded Bimetallic Nanoparticles

Camila P. Ferraz, Natália J. S. Costa, Érico Teixeira‐Neto, Cleber Wanderlei Liria et autres

The heterogeneous catalytic partial oxidation of alcohols and aldehydes in the liquid phase usually needs the addition of a homogeneous base, which in turn makes the products’ recovery cumbersome, and can further induce undesired side reactions. In the present work, we propose …

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O aumento da produtividade e a busca pela excelência na produção do etanol brasileiro: uma história de sucesso

Andres Rosello Gimenez, Luiz Guilherme Altopiedi, Nicolás Versolato Carballo, Leila Cristina Magalhães Silva et autres

Atualmente, o Brasil é líder quando o assunto é produtividade na obtenção de etanol. Os avanços na tecnologia de produção deste biocombustível foram impulsionados por fatores mundiais e nacionais. Um desses fatores foi a criação do Programa Nacional do Álcool (Proálcool) pelo …

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New iminodibenzyl derivatives with anti-leishmanial activity

Anderson Arndt, Cleber Wanderlei Liria, Jenicer K.U. Yokoyama-Yasunaka, Sílvia Reni Bortolin Uliana et autres

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Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron

Roxana Yesenia Pastrana Alta, Hector Aguilar Vitorino, Dibakar Goswami, Cleber Wanderlei Liria et autres

Desferrioxamine (DFO) is a bacterial siderophore with a high affinity for iron, but low cell penetration. As part of our ongoing project focused on DFO-conjugates, we synthesized, purified, characterized and studied new mtDFOs (DFO conjugated to the Mitochondria Penetrating Peptides TAT49-57, 1A, …

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Cadmium decreases the levels of glutathione and enhances the phytochelatin concentration in the marine dinoflagellate Lingulodinium polyedrum

Renato Lahos Romano, Cleber Wanderlei Liria, Pio Colepicolo, Leonardo Zambotti‐Villela

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A green route for the synthesis of a bitter-taste dipeptide combining biocatalysis, heterogeneous metal catalysis and magnetic nanoparticles

Vitor A. Ungaro, Cleber Wanderlei Liria, Carolina D. Romagna, Natália J. S. Costa et autres

The combo protease-metal catalyst-magnetic nanoparticles was used to establish a green alternative synthetic route to produce the bitter taste dipeptide Ala-Phe.

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Análogos da Capsaicina para o Controle de Fungos Deteriorantes de Frutas

Aline Wasem Zanotto, Alessandra Machado Lunkes, Elisabete Hiromi Hashimoto, Cleber Wanderlei Liria et autres

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