R Eugene Johnson

Genetic evidence for a periplasmic protein as a third component for a subset of NtrYX family two-component systems.

Alexa R. Wolber, Peggy A. Cotter, Zain T. Hameed, R Eugene Johnson et autres

PlrSR, a member of the NtrYX family of two-component regulatory systems (TCSs), is required for the classical bordetellae, including the causative agent of whooping cough, Bordetella pertussis, to persist in the lower respiratory tract. The plrSR genes are in the middle of …

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Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins.

Lindsey I. James, Stephen V. Frye, Jiuyang Liu, Cathy J. Spangler et autres

PHF1 and PHF19 are key accessory components of polycomb repressive complex 2 (PRC2) which is responsible for trimethylation at histone H3 lysine 27, ultimately leading to gene repression. PHF1 and 19 are known for their methyl-lysine reader Tudor domains that recognize methylated …

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Discovery and Characterization of Chemical Tools for Chromatin and Kinase Biology

R Eugene Johnson

Validation of potential therapeutic targets is an important first step in expanding the number of druggable targets. The development of chemical tools and chemical probes is a critical activity due to the contribution they can make to target validation and the discovery …

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Abstract 2720: A comprehensive LLM-enabled pharmacodynamic biomarker resource to accelerate cancer drug development.

Yuntao Yang, Li Zhao, Seyedmehdi Orouji, Ying Zhu et autres

Abstract Introduction: A major challenge in oncology drug development is confirming target engagement of therapeutics in patient tumors. Pharmacodynamic (PD) biomarkers provide this link, enabling early assessment of target validity, drug activity and rational dose selection. However, systematic resources connecting drug targets …

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Structure-Guided Development of NRAS G12D Inhibitors Based on a 5-Azaindole Core

Joshua B. Cox, Vinay Nair, Pijus K. Mandal, Naphtali J. Reyna et autres

NRAS G12D mutations are predominantly found in melanoma and hematologic malignancies, and there is an unmet need for developing targeted therapies against this oncogene. Herein, we describe the structure-guided development of IACS-56676, a selective and potent NRAS G12D inhibitor useful as a …

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Call For Help! The Importance of Role Delineation in a Standardized Contrast Media Emergency Response Protocol

Vilert A. Loving, Brian Johnston, Elizabeth Valencia, Shay Dupras et autres

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Medical Imaging Physics, 3rd Ed.

R Eugene Johnson

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