Structure-Guided Development of NRAS G12D Inhibitors Based on a 5-Azaindole Core
Joshua B. Cox, Vinay Nair, Pijus K. Mandal, Naphtali J. Reyna et autres
NRAS G12D mutations are predominantly found in melanoma and hematologic malignancies, and there is an unmet need for developing targeted therapies against this oncogene. Herein, we describe the structure-guided development of IACS-56676, a selective and potent NRAS G12D inhibitor useful as a …
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ACS Medicinal Chemistry Letters