Hannah Johns

Assessment of Cardiorespiratory Exercise Training Intensity on Fitness and Brain Health Markers in Sedentary Middle-Aged Adults

James R. Broatch, Navabeh Zare, Rebecca Glarin, Brad A. Moffat et autres

au (code pays fourni par la source)

Practical guidance for Win Statistics and Tournament Methods for multifaceted outcomes in stroke research: Review and recommendations

Hannah Johns, Vignan Yogendrakumar, Nathalie H. Launder, Kathryn S. Hayward et autres

BACKGROUND: Most stroke trials conventionally use outcome measures that reflect a single point of concern, such as functional outcomes or neurological improvement. Such a focus has a limited capacity to reflect the holistic nature of clinical reality, where multiple facets of health …

au, ca, fr (code pays fourni par la source)

Tenecteplase Efficacy in Patients With Distal Occlusions: Secondary Analysis of the TASTE Randomized Clinical Trial

Vignan Yogendrakumar, Justin YH Phung, Hannah Johns, Leonid Churilov et autres

BACKGROUND: Tenecteplase has been previously evaluated in large- and medium-sized vessel occlusion subgroups, but its effectiveness in more distal occlusions, particularly those involving the distal middle cerebral artery branches or the anterior cerebral artery and posterior cerebral artery territories, and across varying …

au, ca, us, nz, ps, es, tw, fi (code pays fourni par la source)

Cerebral Edema in Patients With Large Ischemic Core After Thrombectomy: A Secondary Analysis of SELECT2 Randomized Trial

Felix Ng, Vignan Yogendrakumar, Hannah Johns, Leonid Churilov et autres

BACKGROUND: Cerebral edema is a life-threatening complication of ischemic stroke that disproportionally affects patients with large established infarction. We assessed whether endovascular thrombectomy (EVT) reduces or exacerbates edema development, and the association between edema with short-term and long-term outcomes in this high-risk …

au, us, ca, es (code pays fourni par la source)

The Epilepsy‐Desirability of Outcome Ranking ( DOOR ) as a Multi‐Faceted Consumer‐Informed Outcome Measure for Epilepsy Clinical Trials

Lucy Vivash, Hannah Johns, Terence O′Brien, Leonid Churilov

BACKGROUND: New drug trials in drug resistant epilepsy are typically powered to detect changes in seizure frequency as the primary endpoint, without integrating other treatment-associated benefits and harms. We developed Epilepsy-DOOR, a consumer-codesigned outcome measure, which combines seizure frequency with quality of …

au (code pays fourni par la source)

Abstract A078: Development of Prognostic Models and Nomograms for Independent Ambulation After Endovascular Thrombectomy in the SELECT2 Trial

Amro Elrefaei, Deep Pujara, Ameer E Hassan, Michael K. Abraham et autres

Background: While endovascular thrombectomy(EVT)improved outcomes for large ischemic strokes in randomized trials, only one in three EVT patients achieved mRS 0-3. Accurate prognostication for patient selection, counseling, and management is difficult with currently available tools and not readily applicable to clinical practice. …

us, es, au, ca (code pays fourni par la source)

Abstract DP364: Association of deep learning segmented ischemic core hypodensity on non-contrast CT with endovascular treatment benefit

Henk van Voorst, Vignan Yogendrakumar, Hannah Johns, Leonid Churilov et autres

Background: Endovascular treatment (EVT) is effective for patients with large ischemic cores caused by a large vessel occlusion. The size and severity of hypodense tissue on non-contrast CT (NCCT) in the ischemic core predict poor outcomes despite successful EVT. Automated ASPECTS tools …

us, ca, au, es (code pays fourni par la source)

Abstract DP025: Differential Actionable Information Yield and Prognostic Value of Perfusion Imaging Ischemic Core Volumes Among EVT Patients with Good and Poor Collaterals – A Secondary Analysis of SELECT2 and SELECT Trial

Deep Pujara, Mohammed A. Almekhlafi, Clark Sitton, Ameer E Hassan et autres

Introduction: Collateral status and perfusion imaging both capture downstream flow in the occluded territory for patients with acute ischemic stroke. Collateral status can be obtained from CT/MR Angiography, which is part of the standard workflow. Perfusion imaging provides quantitative measures of blood …

us, ca, au, es (code pays fourni par la source)

Abstract A031: Non-Contrast CT Severe Hypodensity versus Net Water Uptake in Assessing Thrombectomy Treatment Effect in Large Core Stroke: A Secondary Analysis of the SELECT2 Trial

Vignan Yogendrakumar, BC Campbell, Hannah Johns, Sarthak Singh et autres

Introduction: Severe CT-hypodensity, representing blood-brain-barrier (BBB) injury, has been shown to modify endovascular therapy (EVT) treatment effect in patients presenting with large core stroke. Net water uptake (NWU), reflecting average hypodensity within the lesion, is another measure of BBB injury and has …

ca, au, us, es (code pays fourni par la source)

Abstract A005: Is Tenecteplase More Efficacious than Alteplase for Distal Occlusions? - A Secondary Analysis of the TASTE Trial

Vignan Yogendrakumar, Justin Phung, Hannah Johns, leonid churilov et autres

Introduction: Landmark clinical trials have examined the safety and efficacy of tenecteplase, demonstrating non-inferiority when compared to intravenous alteplase in the < 4.5hr time window. Sub-analysis of tenecteplase performance in large and medium sized occlusions have been performed. However, the efficacy of …

ca, au, nz, es, fi (code pays fourni par la source)

Reporting and Analysis of Process-of-Care Time Measures for Hyperacute Stroke Interventions

Dominic Italiano, Hannah Johns, Bruce Campbell, Guillaume Turc et autres

BACKGROUND: Process-of-care time measures provide important information about hyperacute stroke interventions and performance of systems of care. These measures are often highly skewed, and mean-based summary statistics may be misleading. Percentile-based statistics (eg, median) conveniently and unbiasedly summarize the proportion of patients …

au, fr (code pays fourni par la source)

Calibrated non-inferiority margin: a new pragmatic method to account for population shift in stroke trials

Nuala Peter, Hannah Johns, Bcv Campbell, Bijoy K. Menon et autres

INTRODUCTION: Non-inferiority trials in acute ischemic stroke (AIS) are crucial to improve access to high-quality care. Population shifts must be accounted for when estimating non-inferiority margins, eg, changes in population characteristics (trial vs historical data); however, existing methods have practical and statistical …

de, au, ca (code pays fourni par la source)