Samar S. Fatahala

Pyrrolopyrimidine derivatives as dual COX-2/ACE2 inhibitors: design, synthesis, and anti-inflammatory evaluation

Hala Afifi, Samar S. Fatahala, Rania H. Abd El-Hameed, Shahenda Mahgoub et autres

In this study, we report the design and synthesis of a new series of pyrrolopyrimidine derivatives developed as dual-target nonsteroidal anti-inflammatory agents (NSAIDs). The compounds were evaluated for anti-inflammatory properties, cyclooxygenase-1/2 (COX-1/COX-2) inhibitory activity, and angiotensin-converting enzyme 2 (ACE2)–blocking activity in lipopolysaccharide …

Égypte, ae, sa (code pays fourni par la source)

Amino acid–modified chalcone derivatives with in vitro and in vivo efficacy against colon cancer

Radwan El‐Haggar, Reem I. Alsantali, Ahmed M Aboshanab, Mahmoud Abdelrahman Alkabbani et autres

Égypte, sa, fr (code pays fourni par la source)

Novel Cyanopyrimidine Derivatives as Potential Anticancer Agents

Rania H. Abd El‐Hameed, Omnia Aly, Mariem El Saeed Mohamed, Amal F. Gharib et autres

The Bcl-2 family's anti-apoptotic proteins, particularly Mcl-1, offer a viable avenue for cancer treatment since cancer cells can undergo apoptosis when their selective suppression occurs. Mcl-1 is essential for controlling the advancement of the cell cycle, as well as apoptosis. There is …

Égypte, sa, us (code pays fourni par la source)

Recent Advances in 2(3H)-Furanone Chemistry and Its Hydrazide Derivative: Synthesis and Reactions

Hend Medhat El-Shanbaky, rania Helmy abdelhameed, Mosaad S. Mohamed, Samar S. Fatahala

Synthesis, anti-cancer evaluation and in vitro study of some novel pyrrolo-pyrimidine scaffolds

Mariem El Saeed Mohamed, Samar S. Fatahala, Rania H. Abd El‐Hameed, Hanaa B. Atya et autres

Following their synthesis in good to medium yields, pyrrole-pyrimidine-5-cyano scaffolds (2 and 4) were tested for anti-cancer efficacy using the MTT assay against ovarian cancer (SKOV-3) and breast cancer (MCF-7) cell lines. The IC50 values of 1031.135 µg/mL and 846.4994 μg/mL, respectively, …

Égypte (code pays fourni par la source)

Pyrimidine as a naturally occurring bioactive ring and its importance in different arenas

Mariem El Saeed Mohamed, Samar S. Fatahala, Rania H. Abd El‐Hameed, Mosaad S. Mohamed

The pyrimidine ring is widely known for its biological activity through history, either by itself or attached to other heterocyclic rings. The importance of pyrimidine is due to its presence in the nucleic acid, in addition to its presence in natural and …

Égypte (code pays fourni par la source)

Synthesis, Anti-Cancer Activity, Cell Cycle Arrest, Apoptosis Induction, and Docking Study of Fused Benzo[h]chromeno[2,3-d]pyrimidine on Human Breast Cancer Cell Line MCF-7

Zainab M. Khoder, Mosaad S. Mohamed, Samir M. Awad, Amal F. Gharib et autres

Breast cancer is the predominant form of cancer among women and ranks as the second most prevalent cancer globally, affecting both developed and less developed countries. Presently, accessible cancer treatment methods either employ recently created, secure, and efficient chemotherapeutic medications or directly …

us, Égypte, sa (code pays fourni par la source)

Design, synthesis, molecular modeling, in vitro and in vivo biological evaluation of potent anthranilamide derivatives as dual P-glycoprotein and CYP3A4 inhibitors

Ahmed M. Said, Yara E. Mansour, Radwa R. Soliman, Ridwan Islam et autres

us, Égypte (code pays fourni par la source)

Novel N -Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

Hesham Haffez, Nosaiba A. Elsayed, Marwa F. Ahmed, Samar S. Fatahala et autres

Significant advancements have been made in the domain of targeted anticancer therapy for the management of malignancies in recent times. VEGFR-2 is characterised by its pivotal involvement in angiogenesis and subsequent mechanisms that promote tumour cells survival. Herein, novel N-arylmethyl-aniline/chalcone hybrids 5a–5n …

Égypte, sa, us, kh, fr (code pays fourni par la source)

Design and Synthesis of Some N-4-Substituted Pyrrolopyrimidines with Promising Anticancer Effects

Jaqueline Riad, Mosaad S. Mohamed, Samar S. Fatahala, Yara E. Mansour

The leading cause of death worldwide is reportedly cancer. This deadly, multigenetic condition is characterized by unchecked cell proliferation and differentiation. A family of protein kinases known as tyrosine kinases is essential for cancer cell survival and metastasis. The fibroblast growth factor …

Égypte (code pays fourni par la source)

Pyrimidines as Anticancer and Antiviral: Synthesis & Reactions (A Review)

Samar S. Fatahala, Mosaad S. Mohamed, Marwa Abd El-Fattah Khodair, Rania Abd El-Hameed

Background: The interest of many medicinal and organic chemists has been attracted to the synthesis of pyrimidines and their analogues due to their highly biological and medicinal properties. Objectives& Methodology: Based on these activities, this review discusses the various recent methods for …

Égypte (code pays fourni par la source)

Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19

Shahenda Mahgoub, Samar S. Fatahala, Amira I. Sayed, Hanaa B. Atya et autres

Égypte, ae (code pays fourni par la source)