Toine C. G. Egberts

Patient access to cell and gene therapies through the European hospital exemption pathway in the Netherlands

Christine van Hattem, Lourens T. Bloem, Christianne M.A. Reijnders, Gwylim E.P.J. Janssens et autres

Drug exposure definitions reported in real-world evidence studies on oncology medicines in patients with colorectal cancer: a scoping review

Julia E. M. van Dommelen, Helga Rún Garðarsdóttir, Toine C. G. Egberts, T. J. Giezen

Background: Defining, measuring, and reporting exposure in real-world data are important for the valid generation and interpretation of real-world evidence (RWE). This is especially challenging for oncology medicines, due to complicated treatment regimens and adjustments in dose and/or schedule. This scoping review …

nl, is (code pays fourni par la source)

Changes in systemic medication in children and adolescents with JIA: why, when and which patterns

Merel de Boer, Sytze de Roock, Toine C. G. Egberts, Arief Lalmohamed et autres

OBJECTIVE: To investigate why, when and in which patterns decisions about changes in systemic medications were made in a cohort of JIA patients. METHODS: JIA patients starting first-line systemic therapy were prospectively followed in a Dutch tertiary paediatric rheumatology centre. Treatment lines …

nl (code pays fourni par la source)

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan–Peter van Wieringen, H. J. M. J. (Ineke) Crijns et autres

AIM: Although regulatory responses to safety signals have been studied, pregnancy-specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures. …

nl, us, gb, Afrique du Sud (code pays fourni par la source)

The association between interleukin-6 inhibitors as treatment for COVID-19 and mental health problems in ICU survivors

Thomas G. van Gelder, Arief Lalmohamed, Toine C. G. Egberts, Arjen J. C. Slooter et autres

OBJECTIVE: To assess whether exposure to interleukin-6 (IL-6) inhibitors as treatment for critically ill COVID-19 patients is associated with a lower prevalence of mental health problems one year after ICU admission. DESIGN: Retrospective cohort study using prospectively collected outcome data. SETTING: Two …

nl, us (code pays fourni par la source)

Patients' perspectives and experiences regarding medication reviews: A cross-sectional survey study

Charlotte Falke, Fatma Karapinar‐Çarkit, Wilma Knol, Marcel L. Bouvy et autres

Background: Medication reviews are conducted worldwide to reduce medication-related problems. However, real-world patient perspectives and experiences remain underexplored. This study aimed to explore patients' perspectives and experiences regarding medication reviews and to assess differences across levels of polypharmacy. Methods: A cross-sectional online …

nl, se (code pays fourni par la source)

Response commentary: the effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists

Jeroen P. A. Houwen, Arief Lalmohamed, Toine C. G. Egberts, Michiel Duyvendak et autres

nl (code pays fourni par la source)

Patient preferences and attitudes regarding the environmental impact of medicines: A discrete choice experiment

Milad Sadreghaemy, Daphne Philbert, Eibert Roelof Heerdink, Marcel L. Bouvy et autres

AIMS: Pharmaceutical utilization within global healthcare has significant environmental impact throughout its lifecycle. Understanding how the environmental impact of medicines influences patients' preferences relative to ease of use and cost supports interventions promoting appropriate medicine consumption, reduced waste and environmental sustainability. The …

nl (code pays fourni par la source)

Obituary Ronald Meyboom: A Professional Life Devoted to Pharmacovigilance

Toine C. G. Egberts, Eugène van Puijenbroek, Bert Leufkens

nl (code pays fourni par la source)

Quality of Clinical Information in Pregnancy Pharmacovigilance Data Sources—A Contribution of the ConcePTION Project

Yrea R. J. van Rijt‐Weetink, Jip van Gendt, Toine C. G. Egberts, Florence P. A. M. van Hunsel et autres

PURPOSE: Good documentation of adverse events related to medicines is essential for the assessment of safety signals. Information on the clinical quality of primary pregnancy safety data sources is lacking. The objective of this study was to assess the differences in clinical …

nl, gb, de, Afrique du Sud, ch (code pays fourni par la source)

Patient Preferences and Attitudes Regarding the Environmental Impact of Medicines: A Discrete Choice Experiment

Milad Sadreghaemy, Daphne Philbert, Eibert R. Heerdink, Marcel L. Bouvy et autres

Background The healthcare sector contributes ~5% of global greenhouse gas emissions, with medicines responsible for ~10% throughout their lifecycle. Understanding how the environmental impact of medicines influences patients’ preferences relative to ease of use and cost supports interventions promoting appropriate medicine consumption, …

nl (code pays fourni par la source)

The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists

Jeroen P. A. Houwen, Arief Lalmohamed, Toine C. G. Egberts, Michiel Duyvendak et autres

BACKGROUND: Low-dose (0.5 mg/day) colchicine improves cardiovascular outcomes in patients with stable coronary disease. Around 10-15% of these patients simultaneously use anticoagulant therapy, including vitamin-K antagonists (VKAs). In vitro studies and case reports have described a possible interaction between colchicine and VKAs …

nl (code pays fourni par la source)