Mingdong Wang

Uncovering genes driving developmental stage progression in prostate cancer through spatial transcriptomics

Yongjun Quan, Mingdong Wang, Fan Zou, Hong Zhang et autres

Precisely delineating the transcriptomic profiles of glandular epithelial (GE) cells in prostate cancer (PCa) remains a significant challenge primarily due to their diffuse and multifocal distribution. To address this, we employed spatial transcriptomics (ST) to analyze 12 PCa tissue samples from 10 …

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Enhancing CO2 fixation catalyzed by salicylic acid decarboxylase with remodeled tunnels

Xianglong Li, Hao Huang, Mingdong Wang, Xuanyu Cao et autres

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Research on the Influence of Cracked Control Surface on the Gust Response of High-Aspect-Ratio Flying Wing

Mingdong Wang, X. T. He, Yuguang Bai, Sheng Zhang

Flying-wing aircraft based on high-aspect-ratio wings are a popular configuration for many aerospace engineering applications. Cracked (or cross) control surface structures can adjust the aerodynamic characteristics of flying-wing aircraft. Deep investigations into the effects of such a control surface can provide a …

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Construction of lactylation (LA) risk signature in prostate cancer based on 4D fast DIA L-lactated quantitative genomics

Fan Zou, Yongchen Jin, Yishan Zhang, Mingdong Wang et autres

BACKGROUND: Lactylation (LA) plays a crucial role in regulating protein stability, angiogenesis, and immune modulation. Global lactylation of proteins in prostate cancer cells is a key event in tumor progression. This study aimed to explore the characteristics of LA in patients with …

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Engineering Malic Enzyme CO2 Fixation Activity via a Structure–Sequence–SCANNER (3S) Co-Evolution Strategy

Jianping Shi, Mingdong Wang, Ting Feng, Xianglong Li et autres

Enzymatic CO2 fixation offers great potential for the sustainable synthesis of value-added compounds. Malic enzyme (ME) catalyzes the reverse carboxylation of pyruvate to malate, enabling direct CO2 conversion into C4 compounds with broad biosynthetic applications. However, the reverse carboxylation activity of wild-type …

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Partition optimized design of a hypersonic wing model via thermal-aero-elastic coupling effects

Yuguang Bai, Yongda Chen, X. T. He, Sheng Zhang et autres

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Continuous site mutagenesis of fatty acid photodecarboxylase enables a highly thermostable enzyme for co-solvent-free decarboxylation

Mingdong Wang, Yu Wang, Hao Huang, Xuanyu Cao et autres

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Multisite synergistic evolution of oleate hydratase via DCCM and the orthogonal location of distal sites

Ting Feng, Hao Huang, Ying Xu, Mingdong Wang et autres

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Comparison of safety and effectiveness of medical adhesive and metal spring coil in preoperative localization of peripheral pulmonary nodules

Yifei Wang, Zhenhua Yue, Xiaoqian Shi, Guozhan Xia et autres

Background Accurate preoperative positioning is the key to the success of thoracoscopic surgery for small pulmonary nodules. There are many methods for locating pulmonary nodules in clinical practice, but there are currently few research reports on the value of medical adhesive localization. …

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Optical excitation of metastable krypton using a long-lifetime vacuum ultraviolet lamp

Jianwei Liang, Gaoping Feng, Shandong Qi, Weisheng Xu et autres

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Integrated strategies for engineering ferulic acid decarboxylase with tunnel conformation and substrate pocket for adapting non-natural substrates

Xiaoni Zhu, Yanbin Feng, Mingdong Wang, Shang Li et autres

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Spatial transcriptomics identifies RBM39 as a gene associated with Gleason score progression in prostate cancer

Yongjun Quan, Mingdong Wang, Hong Zhang, Dan Lü et autres

Prostate cancer (PCa) exhibits significant intratumor heterogeneity, frequently manifesting as a multifocal disease. This study utilized Visium spatial transcriptomics (ST) to explore transcriptome patterns in PCa regions with varying Gleason scores (GSs). Principal component analysis (PCA) and Louvain clustering analysis revealed transcriptomic …

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