Fan Zou

Endothelial-specific genes TMTC1, RPS6KA2, and F8 are downregulated in hypertrophic cardiomyopathy

Pingge Tian, Lei Xu, Fan Zou, Jia Qian et autres

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease characterized by left ventricular hypertrophy and excessive myocardial contraction. Endothelial cells (ECs) play a key role in the pathogenesis of HCM, and their secreted growth factors regulate the growth and function of …

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Uncovering genes driving developmental stage progression in prostate cancer through spatial transcriptomics

Yongjun Quan, Mingdong Wang, Fan Zou, Hong Zhang et autres

Precisely delineating the transcriptomic profiles of glandular epithelial (GE) cells in prostate cancer (PCa) remains a significant challenge primarily due to their diffuse and multifocal distribution. To address this, we employed spatial transcriptomics (ST) to analyze 12 PCa tissue samples from 10 …

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Mining of Potential Biomarkers and Pathway in Valvular Atrial Fibrillation (VAF) via Systematic Screening of Gene Coexpression Network

Fan Zou, Tiantian Chen, Xiuying Xiang, Chengjiang Peng et autres

Purpose: We apply the bioinformatics method to excavate the potential genes and therapeutic targets associated with valvular atrial fibrillation (VAF). Methods: The downloaded gene expression files from the gene expression omnibus (GEO) included patients with primary severe mitral regurgitation complicated with sinus …

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Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients

Fan Zou, Jizhu Li, Xiaohua Jie, Xiong Peng et autres

BACKGROUND The expression of miR-205 is closely related to the occurrence, development, and prognosis of lung cancer and breast cancer. However, studies show that it plays opposite roles in different tumor types. Because the expression and regulation of miR-205 are primarily confined …

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[A case of the removing the intragastric foreign body by the gastroscopy combining with the esophagoscopy].

Zhongwan Li, Fan Zou, Xiufu Liao

A male patient, 49 years old with drug use, swallowed a toothbrush and a tube of 20 centimeters long which lead to the upper abdomen pain for six years. The gastroscopy examination showed the head of the toothbrush in the gastric antrum …

Combined laparoscopic and duodenoscopic transcystic duct for common bile duct stone extraction

Fan Zou

Objective To evaluate the efficacy and application of combined laparoscopic and duodenoscopic transcystic duct for common bile duct(CBD) exploration and stone extraction(LTCBDE). Methods Eighty-two patients,diagnosed as gallbladder and CBD stone(s) by MRCP before operation,were treated by LTCBDE. Results LTCBDE was successfully carried …

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Improved laparotomy hysterectomy

Fan Zou

Objective To summarize the clinical experience of improved laparotomy hysterectomy.Methods A total of 98 hysterectomies were improved by mean of the abdominal wall being pulled open bluntly.Shallow vein in abdominal wall was retained.The uterine ligaments were cut off in bundles.The intrafascial hysterectomy …