Toshihide Kashihara

Pharmacological Blockade of Aquaporin-4 Attenuates Na+/K+-ATPase Dysfunction-Induced Inner Retinal Injury in Rats

Ryosuke Odaka, Saori Deguchi, Akane Morita, Toshihide Kashihara et autres

Diabetic retinopathy, a major cause of visual impairment, involves multiple pathological processes, including disruption of water homeostasis regulated by Müller glial cells. Aquaporin-4 (AQP4) is a water channel that mediates passive water transport driven by an osmotic gradient, whereas Na+/K+-ATPase (NKA) maintains …

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Sirt1 inhibits the recruitment of RNA polymerase II to metabolic gene promoter during pressure overload through competition with the preinitiation complex on Sub1

Shinichi Oka, Youssef Mourad, Samta Veera, Peiyong Zhai et autres

AIMS: Heart failure is marked by suppression of fatty acid oxidation (FAO) and mitochondrial ATP production gene expression. While transcriptional downregulation via PGC-1 and PPARα/ERRα has been well documented, the involvement of the general transcriptional machinery remains insufficiently understood. Distinct from its …

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β-Arrestin-biased activation of type I angiotensin II receptors improves prognosis of murine pediatric heart failure

Hiroyuki Kawagishi, Takero Nakajima, Toshihide Kashihara, Daisuke Matsuoka et autres

The pharmacological treatment of pediatric heart failure (PHF) remains a long-standing unmet medical need. We previously reported that TRV027, a peptidyl angiotensin type 1 receptor (AT 1 R) agonist that selectively activates β-arrestin over G protein signaling and avoids G protein-mediated vasoconstriction, …

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Characterization of mitochondrial dysfunction induced by BAX trigger site activator 1 in the ARPE-19 retinal pigment epithelial cell model

Toshihide Kashihara, Yuka Akiyama, Akane Morita, Saori Deguchi et autres

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Differential susceptibility of rat retinal neurons to the Na+/K+-ATPase inhibitor ouabain

Ryosuke Odaka, Akane Morita, Toshihide Kashihara, Tsutomu Nakahara

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Anti-Vascular Endothelial Growth Factor Drugs Restore Glial–Vascular Interaction in a Rat Model of Retinopathy of Prematurity

Saori Deguchi, Akane Morita, Toshihide Kashihara, Tsutomu Nakahara

PURPOSE: Retinopathy of prematurity (ROP), a leading cause of visual impairment and blindness in preterm infants, is characterized by abnormal retinal vascular development, including tortuous arterioles and abnormally dense capillaries. Dysregulated production of vascular endothelial growth factor (VEGF) and disrupted interactions between …

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Protective effects of β-hydroxybutyrate against N-methyl-D-aspartic acid-induced excitotoxic retinal injury in rats

Maiko Mitsufuji, Akane Morita, Toshihide Kashihara, Tsutomu Nakahara

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p22phox prevents the oxidation of SERCA2a and stabilizes it in the heart

Yasuki Nakada, Allen Sam Titus, Wataru Mizushima, Yanfei Yang et autres

Sarcoplasmic/endoplasmic reticulum (SR/ER) Ca2+ ATPase 2a (SERCA2a) mediates Ca2+ reuptake into the SR in cardiomyocytes. The inactivation or downregulation of SERCA2a leads to reduced contractility in the failing heart. Here we show that SERCA2a is regulated by p22phox, a heterodimeric partner of …

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Protective effects of empagliflozin against NMDA-induced excitotoxicity in the rat retina

M. Ota, Akane Morita, Toshihide Kashihara, Tsutomu Nakahara

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YAP activation in Müller cells alleviates oxidative stress in the rat retina after intravitreal injection with methylglyoxal

Toshihide Kashihara, Mayuko Yasaki, Akiko Murayama, Akane Morita et autres

Methylglyoxal (MGO), a highly reactive dicarbonyl compound produced via the glycolytic pathway, plays a key role in the pathogenesis of various diabetic complications, such as diabetic retinopathy. Müller cells provide neurotrophic support and maintain retinal homeostasis, including the redox balance. This dysfunction …

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Pharmacological depletion of pericytes induces diabetic retinopathy-like abnormal blood vessels in neonatal rat retina

Akane Morita, Toshihide Kashihara, Tsutomu Nakahara

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YAP activation in Müller cells protects against NMDA-induced retinal ganglion cell injury by regulating Bcl-xL expression

Toshihide Kashihara, Yui Morita, Misaki Hatta, Sae Inoue et autres

Retinal neurodegeneration, characterized by retinal ganglion cell (RGC) death, is a leading cause of vision impairment and loss in blind diseases, such as glaucoma. Müller cells play crucial roles in maintaining retinal homeostasis. Thus, dysfunction of Müller cells has been implicated as …

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