Alex S. Moreland

Effects of Halogen Substitution on the Antibiotic Characteristics of Conjugated Oligoelectrolytes

Jakkarin Limwongyut, Alex S. Moreland, Kaixi Zhang, Ashelyn E. Sidders et autres

Abstract Conjugated oligoelectrolytes (COEs) are amphiphiles that can exhibit antimicrobial activity. With the view to further develop structure–activity relationships, we report here a series of amidinium COEs with halogen-substituted distyrylbenzene cores and an exploration of the impacts of substitution regiochemistries. We identified …

us, sg, th, fr (code pays fourni par la source)

Mechanosensitive Conjugated Oligoelectrolytes for Visualizing Temporal Changes in Live Cells

Ji‐Yu Zhu, Samuel J. W. Chan, Hongyue Cui, Alexander A. Mikhalovsky et autres

Abstract Membrane‐intercalating conjugated oligoelectrolytes (COEs) are lipid‐bilayer‐spanning molecules that serve as fluorescent dyes for bioimaging. However, COE emission has thus far only been capable of visualizing dye location and their preferential accumulation in different membrane‐bound intracellular compartments. Herein, we report the first …

sg, us (code pays fourni par la source)

Mechanosensitive Conjugated Oligoelectrolytes for Visualizing Temporal Changes in Live Cells

Ji‐Yu Zhu, Samuel J. W. Chan, Hongyue Cui, Alexander A. Mikhalovsky et autres

Membrane-intercalating conjugated oligoelectrolytes (COEs) are lipid-bilayer-spanning molecules that serve as fluorescent dyes for bioimaging. However, COE emission has thus far only been capable of visualizing dye location and their preferential accumulation in different membrane-bound intracellular compartments. Herein, we report the first example …

sg, us (code pays fourni par la source)

Unanticipated Lipid Redistribution Mechanism of Action by Conjugated Oligoelectrolyte Antibiotics

Samuel J. W. Chan, Jakkarin Limwongyut, Alex S. Moreland, Ji‐Yu Zhu et autres

Antimicrobial resistance (AMR) is one of the most pressing global health threats, urgently requiring new classes of antibiotics with differentiated mechanisms of action (MOA). Conjugated oligoelectrolytes (COEs) represent a molecular platform for designing antimicrobial agents structurally distinct from commercially available drugs. However, …

sg, cn, us, bg (code pays fourni par la source)

Redox-active molecules in bacterial cultivation media produce photocurrent

Matthew C. P. Smith, Nathan S. Nasseri, Emile J. Morin, Jakkarin Limwongyut et autres

Renewable energy concepts such as microbial fuel cells (MFCs) present a promising, yet intrinsically complex electrochemical approach for utilizing bacteria as an electron source. In this work, we show that just the cultivation media for bacterial growth, which is based on yeast …

An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus

Kaixi Zhang, Jakkarin Limwongyut, Alex S. Moreland, Samuel J. W. Chan et autres

Infections caused by nontuberculous mycobacteria have increased more than 50% in the past two decades and more than doubled in the elderly population. Mycobacterium abscessus (Mab), one of the most prevalent of these rapidly growing species, is intrinsically resistant to numerous antibiotics. …

sg, us, kr (code pays fourni par la source)

Amidine-Based Cationic Conjugated Oligoelectrolytes with Antimicrobial Activity against Pseudomonas aeruginosa Biofilms

Jakkarin Limwongyut, Alex S. Moreland, Kaixi Zhang, Malik J. Raynor et autres

Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that can cause high-morbidity infections. Due to its robust, flexible genome and ability to form biofilms, it can evade and rapidly develop resistance to antibiotics. Cationic conjugated oligoelectrolytes (COEs) have emerged as a promising class …

us, sg (code pays fourni par la source)

Photophysics of Conjugated Oligoelectrolytes Relevant to Two‐Photon Fluorescence‐Lifetime Imaging Microscopy

Ji‐Yu Zhu, Alexander A. Mikhailovsky, Samuel Chan Jun Wei, Alex S. Moreland et autres

Abstract Conjugated oligoelectrolytes (COEs) comprise a class of cell‐membrane intercalating molecules that serve as effective optical reporters. However, little is known about the photophysical properties of COEs in biological environments such as buffers, cell membranes, and intracellular organelles, which is critical to …

sg, us, es (code pays fourni par la source)

Non-photosynthetic bacteria produce photocurrent mediated by NADH

Yaniv Shlosberg, Jakkarin Limwongyut, Alex S. Moreland, Guillermo Carlos Bazan

Abstract In recent years, the concern from the global climate change has driven an urgent need to develop clean energy technologies that do not involve combustion process that emit carbon into the atmosphere. A promising concept is microbial fuel cells that utilize …

us (code pays fourni par la source)

Structural modulation of membrane-intercalating conjugated oligoelectrolytes decouples outer membrane permeabilizing and antimicrobial activities

Alex S. Moreland, Jakkarin Limwongyut, Samuel J. Holton, Guillermo Carlos Bazan

We report a series of membrane-intercalating conjugated oligoelectrolytes (MICOEs) to probe how structural features impact bacterial membrane integrity and antibiotic activity. Minimum inhibitory concentrations (MICs) and outer membrane (OM) permeability correlated to different structural parameters suggesting that the antimicrobial mechanism is not …

us, sg (code pays fourni par la source)

Redox-active molecules in bacterial cultivation media produce photocurrent

Yaniv Shlosberg, Matthew C. P. Smith, Nathan S. Nasseri, Emile J. Morin et autres

Abstract In recent years, global climate change has urged the importance of developing new clean energy technologies that may replace the combustion of fossil fuels and help to reduce carbon emissions. A promising, yet intrinsically complex solution, is the utilization of bacteria …

us (code pays fourni par la source)

Amide Moieties Modulate the Antimicrobial Activities of Conjugated Oligoelectrolytes against Gram‐negative Bacteria

Jakkarin Limwongyut, Alex S. Moreland, Chenyao Nie, Javier Read de Alaniz et autres

Abstract Cationic conjugated oligoelectrolytes (COEs) are a class of compounds that can be tailored to achieve relevant in vitro antimicrobial properties with relatively low cytotoxicity against mammalian cells. Three distyrylbenzene‐based COEs were designed containing amide functional groups on the side chains. Their …

us, sg (code pays fourni par la source)