Ahmed Alaswad

ZirrFlu cohort - Untargeted metabolites measurement

Ahmed Alaswad

ZirrFlu cohort - Untargeted metabolites measurement

Ahmed Alaswad

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis

L Mayer, Jakob Arnold, Felix Roettele, Nadine Reuter et autres

γδ T cells maintain intestinal immune homeostasis, but their contributions to human ulcerative colitis (UC) are poorly understood. We characterized γδ T cells in intestinal biopsies obtained from patients with UC and healthy donors using single-cell RNA sequencing, T cell receptor profiling, …

de, us, ch, cn, nl (code pays fourni par la source)

A monocyte-derived blood transcriptomic signature reveals systemic immunosuppression in HCC and partial reversal following curative therapy

Liang Zhou, Ahmed Alaswad, Aditi Kumthekar, Dominik A. Machtens et autres

Background Liver ablation or resection can cure early-stage hepatocellular carcinoma (HCC), yet late diagnosis and high relapse rates hinder long-term survival. We sought to delineate how tumor burden—and its removal—reshape the systemic immune transcriptome and extract blood-based signatures with diagnostic and prognostic …

de, nl, us, ca (code pays fourni par la source)

Molecular Signatures of Chronic Antibody-Mediated Rejection in Human Liver Transplants

E. Jaeckel, Bastian Engel, Ahmed Alaswad, Alejandro Campos-Murguía et autres

Purpose: The role of antibody-mediated rejection (ABMR) after liver transplantation (LT) remains controversial. Chronic ABMR (cABMR) is often subclinical and potentially missed without surveillance biopsies (svLbx). Transcriptome analysis previously characterized molecular changes in T cell-mediated rejection (TCMR) after solid organ transplantation. We …

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Interferon gamma rebalances immunopathological signatures in chronic granulomatous disease through metabolic rewiring

Mariolina Bruno, Charlotte Kröger, Anaísa V. Ferreira, Bo-Wen Zhang et autres

ABSTRACT: Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent life-threatening infections and hyperinflammatory complications. It is caused by mutations in the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and the consequent loss of reactive oxygen species (ROS) production. …

nl, de, cn, au, gb, es, ro, ch, pt (code pays fourni par la source)

Molecular signatures discriminating different types of rejection in human liver transplants

Bastian Engel, Ahmed Alaswad, Alejandro Campos-Murguía, Martijn Zoodsma et autres

BACKGROUND & AIMS: The role of antibody-mediated rejection (AMR) after liver transplantation (LT) remains controversial. Chronic AMR (cAMR) is often subclinical and may be missed without surveillance biopsies (svLbx). Transcriptome analyses have previously characterized molecular changes in T cell-mediated rejection (TCMR) after …

de, us, dk, nl (code pays fourni par la source)

Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination

Cancan Qi, Zhaoli Liu, Gizem Kılıç, Andrei S. Sarlea et autres

BACKGROUND: Epigenetic reprogramming shapes immune memory in both innate (trained immunity) and adaptive immune cells following Bacillus Calmette-Guérin (BCG) vaccination. However, the role of dynamic DNA methylation changes in post-vaccination immune responses remains unclear. RESULTS: We established a cohort of 284 healthy …

de, cn, nl, ro (code pays fourni par la source)

OS-092-YI The transcriptomic profile of antibody-mediated rejection is independent from the presence of donor specific antibodies

Bastian Engel, Alejandro Campos-Murguía, Ahmed Alaswad, Alisa Kielkowski et autres

Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination

Wenchao Li, Zhenhua Zhang, Saumya Dileep Kumar, Javier Botey-Bataller et autres

Abstract Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately reflect immune function, their relationship with biological immune aging and health status remains unclear. Here we developed robust, cell-type-specific aging clocks (sc-ImmuAging) for the myeloid …

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Integrative analysis reveals the multilateral inflammatory mechanisms of CD14 monocytes in gout

Ahmed Alaswad, Georgiana Cabău, Tania O. Crișan, Liang Zhou et autres

OBJECTIVES: Gout, prevalent inflammatory arthritis caused by urate crystal deposition, involves immune cell activation, yet the precise role of CD14 monocytes in initiating the inflammatory response is poorly understood. This study aimed to characterise the molecular and cellular landscape of CD14 monocytes …

de, ro, nl, us, nz (code pays fourni par la source)

P0001 Single-cell profiling reveals distinct γδ T cell subsets with protective and pathogenic roles in Ulcerative Colitis

L Mayer, Jack Arnold, Nina Reuter, Ajinkya Pattekar et autres

Abstract Background Comprising about 40% of mucosal lymphocytes, γδ T cells represent a significant lineage in the gut, and thus are key players in the intestinal immune homeostasis. In contrast to αβ TCRs, γδ TCRs are able to recognize antigen independent from …

de, us, ch (code pays fourni par la source)