Min‐Hui Liu

Activation of the phenylalanine metabolic axis is associated with adverse clinical outcomes and mitochondria-dependent bioenergetic deficiency in ischemic cardiomyocytes

Wan-Tseng Hsu, Min‐Hui Liu, Kun‐Yi Chien, Chi‐Ying Lee et autres

Elevated plasma phenylalanine (PHE) is associated with adverse outcomes in heart failure (HF), but whether PHE is only a marker of systemic severity or can modify ischemic vulnerability remains unclear. We evaluated the prognostic value of the PHE–phenylpyruvate (PPA) axis and examined …

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Reduced readmission persists for 2 years after completion of a multidisciplinary heart failure management programme

Min‐Hui Liu, Chao‐Hung Wang, Wan-Tseng Hsu

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Dietary intervention to attenuate inflammation in patients with hyperphenylalaninemia in ICU: a preliminary study

Chao‐Hung Wang, Min‐Hui Liu, Yi‐Tsen Lin, Wei-Siang Chen et autres

Inflammation severity predicts mortality risk in intensive care unit (ICU) patients. Hyperphenylalaninemia (HPA) is associated with inflammation. We investigated whether a phenylalanine (PHE)-free diet (PFD) reduces PHE, downstream metabolite, and proinflammatory cytokine levels in patients with HPA. This study enrolled ICU patients …

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CROSS-CULTURE ADAPTATION AND VALIDATION OF THE CHINESE VERSION OF MANCHESTER COPD FATIGUE SCALE (MCFS)

Haihong Zhang, Chongmei Huang, Min‐Hui Liu

Abstract Fatigue is an aching, complex, and multifaceted sensation that is the second most prominent and disabling symptom of COPD, approximately 50% of COPD patients suffer from severe fatigue. Various scales or questionnaires has been developed to measure fatigue in COPD patients. …

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Extensive Dysregulation of Phenylalanine Metabolism Is Associated With Stress Hyperphenylalaninemia and 30‐Day Death in Critically Ill Patients With Acute Decompensated Heart Failure

Wei‐Siang Chen, Min‐Hui Liu, Yi‐Liang Tsou, Huang-Pin Wu et autres

Background Stress hyperphenylalaninemia predicts elevated mortality rates in patients with acute decompensated heart failure (ADHF). This study investigated the metabolic pathways underlying this association and identified a unique metabolic phenotype underlying the association between stress hyperphenylalaninemia and adverse outcomes in ADHF. Methods …

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Prognostic Significance of Phenylalanine in Heart Failure: Clinical Insights and Inter-Organ Crosstalk Snapshot

Jih‐Kai Yeh, Yi‐Liang Tsou, Min‐Hui Liu, Wei-Siang Chen et autres

Background: Heart failure (HF) remains a leading cause of morbidity and mortality globally, necessitating the identification of reliable prognostic biomarkers to guide therapeutic interventions. Recent clinical observations have underscored phenylalanine (PHE) as a prognostic marker in HF, although the mechanisms involving inter-organ …

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Improved UNet‐based magnetic resonance imaging segmentation of demyelinating diseases with small lesion regions

Min‐Hui Liu, Tianlei Wang, Dekang Liu, Feng Gao et autres

Abstract Accurate magnetic resonance imaging (MRI) segmentation plays a critical role in the diagnosis and treatment of demyelinating diseases. But the existing automatic segmentation methods are not suitable for the segmentation of demyelinating lesions with small lesion size, highly diffuse edges and …

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The Mediator Role of Meaning in Life in the Life Quality of Patients With Chronic Heart Failure

Min‐Hui Liu, Chao‐Hung Wang, Ai‐Fu Chiou

PURPOSE: Heart failure (HF) is a highly recurrent disease with a high sudden death rate and a substantial influence on disease-related quality of life (QOL). Social support, symptom distress, care needs, and meaning in life all have significant impacts on QOL. We …

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The Lived Experience of Frailty in Patients Aged 60 Years and Older with Heart Failure: A Qualitative Study

Hsuan Su, Huei-Fong Hung, Shu‐Pen Hsu, Min‐Hui Liu et autres

PURPOSE: The prevalence of frailty among patients with heart failure is about 45%. Frailty may result in patients' functional decline, falls, disability, and decreased quality of life. Qualitative studies can explore older patients' perceptions of frailty and help patients cope with it. …

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Research on Bird Nest Image Recognition and Detection Technology of Transmission Lines Based on Improved Faster-RCNN Algorithm

Zhilong Zhang, Hongxia Ni, Min‐Hui Liu, Zimeng Zhang et autres

Under certain circumstances, the branches, iron wire, and firewood used by birds in the transmission line will reduce the insulation level of the line, cause the discharge of the wire and cause the trip of the line, which poses a serious threat …

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Combining Phenylalanine and Leucine Levels Predicts 30-Day Mortality in Critically Ill Patients Better than Traditional Risk Factors with Multicenter Validation

Yi‐Liang Tsou, Chao‐Hung Wang, Wei-Siang Chen, Huang-Pin Wu et autres

In critically ill patients, risk scores are used; however, they do not provide information for nutritional intervention. This study combined the levels of phenylalanine and leucine amino acids (PLA) to improve 30-day mortality prediction in intensive care unit (ICU) patients and to …

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Empagliflozin and Left Ventricular Remodeling in People Without Diabetes: Primary Results of the EMPA-HEART 2 CardioLink-7 Randomized Clinical Trial

Kim Alexander Connelly, C. David Mazer, Pankaj Puar, Hwee Teoh et autres

Background: Sodium-glucose cotransporter 2 inhibitors have been demonstrated to promote reverse cardiac remodeling in people with diabetes or heart failure. Although it has been theorized that sodium-glucose cotransporter 2 inhibitors might afford similar benefits in people without diabetes or prevalent heart failure, …

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