Prognostic Significance of Phenylalanine in Heart Failure: Clinical Insights and Inter-Organ Crosstalk Snapshot
Rattachement africain : tw. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Heart failure (HF) remains a leading cause of morbidity and mortality globally, necessitating the identification of reliable prognostic biomarkers to guide therapeutic interventions. Recent clinical observations have underscored phenylalanine (PHE) as a prognostic marker in HF, although the mechanisms involving inter-organ crosstalk remain understood. Methods: This study adopted a dull approach, with a retrospective analysis of 550 HF patients to establish the prognostic value of pre-discharge PHE levels and a study on the inter-organ crosstalk of PHE among 24 patients. We analyzed the correlations between PHE concentrations and clinical outcomes, alongside a comprehensive examination of PHE metabolism across the skeletal muscle, liver, heart, kidney, and lung. Results: In the clinical prognostic analysis of 550 patients hospitalized for acute decompensated HF, elevated PHE levels (≥65.6 μM) were significantly and independently associated with increased all-cause mortality during a median follow-up of 4.5 years (log rank = 36.7, p < 0.001), underscoring its value as a prognostic marker in HF. The inter-organic crosstalk study elucidated the mechanism associated with PHE elevation in patients with HF, characterized by an increase in PHE output in skeletal muscle and a decrease in hepatic and cardiac PHE uptakes. Notably, PHE concentration gradients across these organs were correlated with HF severity, such as the NYHA functional class, B-type natriuretic peptide levels, and the presence of acute HF. Conclusions: Our findings confirm the prognostic significance of PHE in patients with HF and unveil the complex metabolic interplay among key organs that contribute to PHE dysregulation. These insights not only reinforce the importance of metabolic monitoring in HF management but also open avenues for therapeutic targets.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prognostic Significance of Phenylalanine in Heart Failure: Clinical Insights and Inter-Organ Crosstalk Snapshot
- Date Crossref
- 21/07/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Chang Gung Memorial Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
-
Keelung Chang Gung Memorial Hospital pays non établi dans la noticeÉtablissement de santé
-
Chang Gung University pays non établi dans la noticeUniversité ou école supérieure
-
Kaohsiung Chang Gung Memorial Hospital pays non établi dans la noticeÉtablissement de santé
-
Chiayi Chang Gung Memorial Hospital pays non établi dans la noticeÉtablissement de santé
-
Heart Failure Research Center pays non établi dans la noticeStructure de recherche
-
School of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Internal Medicine — Chang Gung Memorial Hospital, Keelung Chang Gung Memorial Hospital et Chang Gung University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.