Yi‐Tsen Lin

Development and Validation of a Simplified Three‐Item Score for Predicting Eosinophilic Chronic Rhinosinusitis

Kao‐Tsung Lin, Yi‐Chen Tsai, Te‐Huei Yeh, Chih‐Feng Lin et autres

ABSTRACT Objective Accurate preoperative identification of eosinophilic chronic rhinosinusitis (ECRS) is essential for treatment planning and selection of biologic therapies, particularly in Asian populations where inflammatory endotypes are more heterogeneous. We aimed to develop and validate a simplified clinical scoring system using …

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Dietary intervention to attenuate inflammation in patients with hyperphenylalaninemia in ICU: a preliminary study

Chao‐Hung Wang, Min‐Hui Liu, Yi‐Tsen Lin, Wei-Siang Chen et autres

Inflammation severity predicts mortality risk in intensive care unit (ICU) patients. Hyperphenylalaninemia (HPA) is associated with inflammation. We investigated whether a phenylalanine (PHE)-free diet (PFD) reduces PHE, downstream metabolite, and proinflammatory cytokine levels in patients with HPA. This study enrolled ICU patients …

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The Role of Race and Ethnicity in Chronic Rhinosinusitis With Nasal Polyps: A Scoping Review

Arthur W. Wu, Mishek Thapa, Mahdi Al‐Ghezi, Eugene Oh et autres

Background Race or ethnicity may influence chronic rhinosinusitis (CRS) endotype. Asian patients with CRS with nasal polyps (CRSwNP) may have increased Th1/Th17/mixed endotypes. However, there is a paucity of research concerning the endotype of non-Caucasian and non-Asian patients. Objective This review seeks …

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Endotypes of Chronic Rhinosinusitis: A Clinical Perspective

C.-C. Liu, Yi‐Tsen Lin, Steven Chun‐Kang Liao, Kao‐Tsung Lin et autres

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The Efficacy of Dupilumab as an Adjuvant Treatment After Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps: A Retrospective Cohort Analysis

Chin-Nung Liu, Te‐Huei Yeh, Chih‐Feng Lin, Yi‐Tsen Lin

OBJECTIVES: Chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrates a high recurrence rate following endoscopic sinus surgery (ESS). The role of adjunctive biologic therapy remains incompletely understood. This study aims to assess the efficacy of dupilumab when used in conjunction with ESS for …

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Innovative Approache to Nasal Septum Surgery: Use of 3D Printed Polyurethane Scaffold for Cartilage Reconstruction

Yi‐Tsen Lin

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Multiple instance learning for eosinophil quantification of sinonasal histopathology images: A hierarchical determination on whole slide images

Yen‐Chi Hsu, Kao‐Tsung Lin, Ming‐Sui Lee, Li‐Sung Shen et autres

KEY POINTS: We proposed a hierarchical framework including an unsupervised candidate image selection and a weakly supervised patch image detection based on multiple instance learning (MIL) to effectively estimate eosinophil quantities in tissue samples from whole slide images. MIL is an innovative …

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Modified screening and management strategies for chronic rhinosinusitis in hematologic patients receiving hematopoietic stem cell transplantation

Yen‐Hui Lee, Chih-Feng Lin, Te‐Huei Yeh, Huai‐Hsuan Huang et autres

OBJECTIVES: Given the lack of consensus on the screening and treatment for chronic rhinosinusitis (CRS) in the patients undergoing hematopoietic stem cell transplantation (HSCT), we reviewed the risk factors for CRS to improve the efficiency of sinonasal screening and analyzed the effect …

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Comprehensive evaluation of type 2 endotype and clinical features in patients with chronic rhinosinusitis with nasal polyps in Taiwan: a cross-sectional study

Yi‐Tsen Lin, Chih‐Feng Lin, Steven Chun‐Kang Liao, Te‐Huei Yeh

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Recent Updates of Immunotherapy for Allergic Rhinitis in Children

Chih‐Feng Lin, Yi‐Tsen Lin, Steven Chun‐Kang Liao, Te‐Huei Yeh

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Multi-instance learning for eosinophil quantification of sinonasal histopathology images

Yi‐Tsen Lin, Ming‐Sui Lee, Te‐Huei Yeh

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The link between allergic rhinitis and chronic rhinosinusitis

David Robert Grimm, Peter H. Hwang, Yi‐Tsen Lin

PURPOSE OF REVIEW: Allergic rhinitis and chronic rhinosinusitis (CRS) are common disorders affecting millions of people worldwide. Although allergic rhinitis and CRS are distinct clinical entities, certain CRS endotypes share similar pathological mechanisms as those seen in patients with allergic rhinitis. This …

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