Jessica M. Miller

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne Hille et autres

Heart failure with preserved ejection fraction (HFpEF) is a prevalent and complex syndrome, with metabolic dysfunction playing a pivotal role in its progression. Disrupted endoplasmic reticulum (ER) homeostasis is recognized as a central mechanism in its pathogenesis. Although the homologous kinases Pak1 …

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CRISPR-Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function after myocardial infarction

Mario D.G. Escobar, Saad A. Malik, Mira A. Srinivasa, Miguel Mendez-Sosa et autres

Insufficient energy supply due to impaired mitochondria has emerged as a key pathological factor in the development of heart failure (HF) after myocardial infarction (MI). Unfortunately, no current therapeutic strategies directly augment myocardial energy production. While mitochondrial biogenesis is orchestrated by the …

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Abstract Thu024: Spontaneously proliferating cardiomyocytes are sensitized to proliferate through retinoic acid dependent signaling

Abou Bakr M. Salama, Qinghui Ou, Marc Dwenger, Collin Wells et autres

Introduction: Adult Cardiomyocytes (CMs) are post-mitotic cells, hence cardiac insults usually progress to heart failure. In contrary, spontaneously cycling CMs are a distinct population in the neonatal heart that has been reported but the molecular mechanisms regulating their cell cycle activity remain …

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Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He et autres

BACKGROUND AND PURPOSE: Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1-7, has an unclear role in cardiac …

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Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity

Lynn Devilée, Abou Bakr M. Salama, Jessica M. Miller, Janice D. Reid et autres

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CD36-Retinoic Acid- FABP5- PPARδ Signaling Axis Primes Neonatal Cardiomyocytes to Spontaneously Proliferate

Abou Bakr M. Salama, Qinghui Ou, Riham Abouleisa, Tamer Mohamed et autres

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Clinical and Neurophysiological Effects of Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Depression

Luke J. Hearne, Lachlan Webb, Robin Cash, Conor Robinson et autres

INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an established treatment for refractory major depressive disorder (MDD), but treatment outcomes vary substantially from person to person. Recent evidence suggests that incorporating neuroimaging-based targeting may help improve …

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XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity

Oveena Fonseka, Rida Raja, C. A. Ross, Sanskruti Ravindra Gare et autres

BACKGROUND: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes are limited. Intramyocardial lipotoxicity contributes to cardiac dysfunction. Here, we investigate the mechanisms underlying EDEM2 (endoplasmic …

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Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity

Lynn Devilée, Abou Bakr M. Salama, Jessica M. Miller, Janice D. Reid et autres

Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity. Calcium is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. Here we show a robust …

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Advanced Lightweight Attention for Segmentation

Jessica M. Miller, Smith Lance, Aisha Khan

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PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity CardiomyopathyShort Title: PAK3 provokes cardiac lipotoxicity

Xinyi Chen, Andrea Ruiz‐Velasco, Susanne Hille, Claire Ross et autres

Abstract Obesity-induced lipid overload in cardiomyocytes contributes to profound oxidative stress and cardiomyopathy, culminating in heart failure. In this study, we investigate a novel mechanism whereby lipids accumulate in cardiomyocytes and seek the relevant treatment strategies. P21-activated kinase 3 (PAK3) was elevated …

PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity CardiomyopathyShort Title: PAK3 provokes cardiac lipotoxicity

Xinyi Chen, Andrea Ruiz‐Velasco, Zhiyong Zou, Susanne Hille et autres

Abstract Obesity-induced lipid overload in cardiomyocytes contributes to profound oxidative stress and cardiomyopathy, culminating in heart failure. In this study, we investigate a novel mechanism whereby lipids accumulate in cardiomyocytes and seek the relevant treatment strategies. P21-activated kinase 3 (PAK3) was elevated …