Yingjuan Liu

Advances and Prospects of Cardiac Organoids in Drug Development

Xiaoying Liu, Yingjuan Liu, Yutong Yan, Fay Pu et autres

Cardiovascular diseases (CVDs) are the leading cause of death globally, propelling the urgent need for more effective drug development strategies. Traditional methods, such as two-dimensional (2D) cell cultures and animal models, fall short due to their limited structural complexity, lack of physiological …

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A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne Hille et autres

Heart failure with preserved ejection fraction (HFpEF) is a prevalent and complex syndrome, with metabolic dysfunction playing a pivotal role in its progression. Disrupted endoplasmic reticulum (ER) homeostasis is recognized as a central mechanism in its pathogenesis. Although the homologous kinases Pak1 …

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Traditional Chinese Medicine for Cancer-Related Fatigue: Evidence, Mechanisms, and Clinical Translation

Lei Huang, Ruxue Fang, Yingjuan Liu, Wenjuan Yang

Cancer-related fatigue (CRF) is one of the most prevalent and distressing symptoms experienced by patients with cancer and cancer survivors. It is characterized by persistent physical, emotional, and cognitive exhaustion that is disproportionate to recent activity and is not sufficiently relieved by …

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407 Establishing a human embryonic stem cell model of TBX1 deficiency to investigate the pathogenesis of congenital heart disease

Mingwei Li, Yingjuan Liu, David Talevera, Sabu Abraham et autres

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BS11 Unravelling the role of HCN4-NPTN promoter interactions in regulation of heart rate

Alysha E. Burrows, Yingjuan Liu, James Eales, Bernard Keavney et autres

Choy et al., (2018) used promoter capture HiC to uncover the promoter interactome of human embryonic stem cell derived cardiomyocytes (hESC-CMs), thus unveiling key regulators of cardiomyocyte gene expression. Promoter interacting regions (PIR) in cardiomyocytes were found to overlap significantly with GWAS …

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Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He et autres

BACKGROUND AND PURPOSE: Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1-7, has an unclear role in cardiac …

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Human Cardiac Organoids: Quantification and Qualification in Cardiovascular Studies

Yingjuan Liu, Sabu Abraham, Honglin Xu

Review Human Cardiac Organoids: Quantification and Qualification in Cardiovascular Studies Yingjuan Liu, Sabu Abraham, and Honglin Xu * Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK. * Correspondence: honglin.xu@postgrad.manchester.ac.uk Received: 4 April 2024; …

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BS35 Get: a generic deep learning-based edge detection and optical tracking toolbox for 3D cardiac organoids and genetic investigations

Yingjuan Liu, Siew Hon Teay, Bernard Keavney

Introduction To reduce the use of animals in basic cardiovascular research, the applications of in vitro 3D cardiac organoids (COs) in heart disease modelling and drug screenings are increasing incrementally. However, the electrophysiological recording of 3D COs is still challenging and very …

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Abstract 16686: A Novel Co-Culture 3D Cardiac Organoid Models Early Heart Development

Yingjuan Liu, Honglin Xu, Bernard Keavney

Introduction: Embryoid body-derived cardiac organoids (CO), incorporating complex chamber-like structures, have been reported since 2021. By contrast, co-culture COs described so far, which have been assembled from primary or hESC derived-cardiomyocytes, endothelial and fibroblast cells, lack complex structures. Cells of the endocardial …

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Progress of 3D Organoid Technology for Preclinical Investigations: Towards Human In Vitro Models

Yingjuan Liu, Honglin Xu, Sabu Abraham, Xin Wang et autres

Review Progress of 3D Organoid Technology for Preclinical Investigations: Towards Human In Vitro Models Yingjuan Liu *, Honglin Xu, Sabu Abraham, Xin Wang, and Bernard D. Keavney* Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PT, …

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Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation

Yingjuan Liu, Mun‐Kit Choy, Sabu Abraham, Gennadiy Tenin et autres

This article presents data concerning STX18-AS1, a long noncoding RNA gene identified from a Genome-wide association study of Atrial Septal Defect (ASD). The data describes its expression patterns in human tissues and functions in regulating cardiomyocyte differentiation in vitro. STX18-AS1 is a …

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Atrial Septal Defect (ASD) associated long non-coding RNA STX18-AS1 maintains time-course of in vitro cardiomyocyte differentiation

Yingjuan Liu, Mun‐Kit Choy, Sabu Abraham, Gennadiy Tenin et autres

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