Su‐Nam Kim

Reversible arginine methylation of PI3KC2α controls mitotic spindle dynamics

Yena Cho, Jee Won Hwang, Mark T. Bedford, Dong Hee Na et autres

Microtubules, composed of αβ-tubulin dimers, undergo dynamic polymerization and are fundamental to cell structure and function. In the current study, we discovered that phosphatidylinositol 3-kinase class 2α (PI3KC2α) acts as a novel regulatory factor in microtubule dynamics. Specifically, asymmetric dimethylation of PI3KC2α …

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Notoginsenoside Ft1 induces lysosomal cell death and apoptosis by inhibiting the PI3K/AKT/mTOR pathway in hepatocellular carcinoma

Youngsic Jeon, Hyukjoon Kwon, Taek Chung, Young Nyun Park et autres

Notoginsenoside Ft1 (NFt1) is a bioactive compound derived from Panax notoginseng, a traditional medicinal herb that exhibits various pharmacological properties, including anti-inflammatory and anticancer effects. However, its effects on hepatocellular carcinoma (HCC) remain poorly understood. This study sought to investigate the anticancer …

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Isolation, Characterization, and Anti-Allergic Evaluation of Phytochemicals from Wikstroemia trichotoma

Min-Ji Keem, Tae‐Young Kim, No-June Park, Sangho Choi et autres

Background/Objectives: The Wikstroemia genus has been traditionally used in Asia to treat various ailments, including parotitis, pneumonia, and pertussis. These plants contain many bioactive compounds, including flavonoids, coumarins, and lignans. This study investigates the chemical components of a MeOH extract of the …

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CARM1 S217 phosphorylation by CDK1 in late G2 phase facilitates mitotic entry

Yena Cho, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim

The coactivator-associated arginine methyltransferase 1 (CARM1) functions as an epigenetic writer, however, its role in mitosis remains poorly understood. In this study, we identified CARM1 as a novel substrate of cyclin-dependent kinase 1 (CDK1) and revealed its novel function as a scaffold …

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CARM1 regulates tubulin autoregulation through PI3KC2α R175 methylation

Yena Cho, Jee Won Hwang, Mark T. Bedford, Dae‐Geun Song et autres

Tubulin is crucial in several cellular processes, including intracellular organization, organelle transport, motility, and chromosome segregation. Intracellular tubulin concentration is tightly regulated by an autoregulation mechanism, in which excess free tubulin promotes tubulin mRNA degradation. However, the details of how changes in …

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Melatonin’s Impact on Wound Healing

Eun‐Hwa Sohn, Su‐Nam Kim, Sung Ryul Lee

Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various …

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Inhibitory effects of compounds isolated from Geranium wilfordii on IL-4 production and β-hexosaminidase release in RBL-2H3 cells

Hyeon Goo Kang, Beom-Geun Jo, Tae‐Young Kim, Su‐Nam Kim et autres

This study aimed to investigate the anti-allergic activity of compounds isolated from Geranium wilfordii Maxim. and to suggest potential therapeutic agents for allergies. Nine compounds were isolated from an ethanolic G. wilfordii extract using chromatographic methods and identified chemically and by spectroscopic …

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Cobrotoxin, a single peptide from snake venom, ameliorates atopic dermatitis via suppression of MK2 modulated by IgE and IL-33

Jin Woo Lee, Young-Hoon Choi, Sang Heon Lee, No-June Park et autres

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Reversal of stress- or chemotherapy-induced immunosuppression by socheongryong-tang aqueous extract

Youngsic Jeon, Hyeonseok Ko, Dong-Young Woo, Taejung Kim et autres

Abstract Socheongryong-tang (SCRT) has been recognized as a traditional medication for managing chills and fever in East Asian countries, including Korea, China, and Japan. This study aimed to elucidate the novel biological activity and mode of action underlying the immunity-boosting effects of …

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D-Pinitol mitigates post-traumatic stress disorder-like behaviors induced by single prolonged stress in mice through mineralocorticoid receptor antagonism

Chang Hyeon Kong, Jin Woo Lee, Mijin Jeon, Woo Chang Kang et autres

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Artificial Octopus-Limb-Like Adhesive Patches for Cupping-Driven Transdermal Delivery with Nanoscale Control of Stratum Corneum

Gui Won Hwang, Bum Soo Lee, No-June Park, Su‐Nam Kim et autres

Drug delivery through complex skin is currently being studied using various innovative structural and material strategies due to the low delivery efficiency of the multilayered stratum corneum as a barrier function. Existing microneedle-based or electrical stimulation methods have made considerable advances, but …

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Iridoid Glycosides and Coumarin Glycoside Derivatives from the Roots of Nymphoides peltata and Their In Vitro Wound Healing Properties

Tae‐Young Kim, Bum Soo Lee, Beom-Geun Jo, Seong Pil Heo et autres

Nymphoides peltata has been used as a medicinal herb in traditional medicines to treat strangury, polyuria, and swelling. The phytochemical investigation of the MeOH extract of N. peltata roots led to the isolation of three iridoid glycosides and three coumarin glycoside derivatives, …

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