Artificial Octopus-Limb-Like Adhesive Patches for Cupping-Driven Transdermal Delivery with Nanoscale Control of Stratum Corneum
Rattachement africain : kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Drug delivery through complex skin is currently being studied using various innovative structural and material strategies due to the low delivery efficiency of the multilayered stratum corneum as a barrier function. Existing microneedle-based or electrical stimulation methods have made considerable advances, but they still have technical limitations to reduce skin discomfort and increase user convenience. This work introduces the design, operation mechanism, and performance of noninvasive transdermal patch with dual-layered suction chamber cluster ( d- SCC) mimicking octopus-limb capable of wet adhesion with enhanced adhesion hysteresis and physical stimulation. The d- SCC facilitates cupping-driven drug delivery through the skin with only finger pressure. Our device enables nanoscale deformation control of stratum corneum of the engaged skin, allowing for efficient transport of diverse drugs through the stratum corneum without causing skin discomfort. Compared without the cupping effect of d- SCC, applying negative pressure to the porcine, human cadaver, and artificial skin for 30 min significantly improved the penetration depth of liqui d- formulated subnanoscale medicines up to 44, 56, and 139%. After removing the cups, an additional acceleration in delivery to the skin was observed. The feasibility of d- SCC was demonstrated in an atopic dermatitis-induced model with thickened stratum corneum, contributing to the normalization of immune response.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Artificial Octopus-Limb-Like Adhesive Patches for Cupping-Driven Transdermal Delivery with Nanoscale Control of Stratum Corneum
- Date Crossref
- 22/01/2024
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sungkyunkwan University Samsung Advanced Institute for Health Science & Technology (SAIHST) pays non établi dans la noticeUniversité ou école supérieure
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Korea Institute of Science and Technology pays non établi dans la noticeStructure de recherche
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Korea National University of Transportation Department of Electronic Engineering pays non établi dans la noticeUniversité ou école supérieure
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Pohang University of Science and Technology Department of Chemical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Samsung (South Korea) pays non établi dans la noticeEntreprise
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School of Chemical Engineering pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Natural Products Research Institute pays non établi dans la noticeStructure de recherche
Samsung Advanced Institute for Health Science & Technology (SAIHST) — Sungkyunkwan University, Korea Institute of Science and Technology et Department of Electronic Engineering — Korea National University of Transportation, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.