Isolation, Characterization, and Anti-Allergic Evaluation of Phytochemicals from Wikstroemia trichotoma
Rattachement africain : kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background/Objectives: The Wikstroemia genus has been traditionally used in Asia to treat various ailments, including parotitis, pneumonia, and pertussis. These plants contain many bioactive compounds, including flavonoids, coumarins, and lignans. This study investigates the chemical components of a MeOH extract of the aerial parts of Wikstroemia trichotoma (Thunb.) Makino and evaluates their anti-inflammatory and anti-allergic effects in vitro. Methods: Chromatographic techniques, spectroscopic analysis, and the literature were used to isolate compounds from the branches and leaves of W. trichotoma. IL-4 mRNA and β-hexosaminidase levels were assessed by performing assays on RBL-2H3 cells to evaluate anti-inflammatory and anti-allergic potential. Results: Forty-two compounds were isolated from the W. trichotoma extract, and the flavanones trichotocinol A and B were newly identified. Screening of isolated compounds showed that several significantly inhibited DNP-BSA-induced β-hexosaminidase release by 10.0–58.0% and PMA/ionomycin-induced IL-4 mRNA expression by 25.3–71.7% versus negative controls. In addition, trichotocinol A reduced IL-4 mRNA expression by 31.9%. Conclusions: The discovery of these new compounds contributes to our understanding of the bioactive properties of W. trichotoma and suggests their potential use as natural therapeutic agents for inflammatory disorders.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Isolation, Characterization, and Anti-Allergic Evaluation of Phytochemicals from Wikstroemia trichotoma
- Date Crossref
- 30/04/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Pusan National University pays non établi dans la noticeUniversité ou école supérieure
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Korea Institute of Science and Technology pays non établi dans la noticeStructure de recherche
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Korea Research Institute of Bioscience and Biotechnology pays non établi dans la noticeStructure de recherche
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College of Pharmacy Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Natural Products Research Institute pays non établi dans la noticeStructure de recherche
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International Biological Material Research Center pays non établi dans la noticeStructure de recherche
Pusan National University, Korea Institute of Science and Technology et Korea Research Institute of Bioscience and Biotechnology, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.