Tixiao Wang

Correction to: Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway

Wenjiang Yan, Jingjing Yang, Siyu Tan, Tixiao Wang et autres

cn, us, bd (code pays fourni par la source)

Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway

Wenjiang Yan, Jingjing Yang, Siyu Tan, Tixiao Wang et autres

cn, us, bd (code pays fourni par la source)

BRD4 Signaling Maintains the Differentiated State of β Cells

Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun et autres

In diabetes, pancreatic β cells degenerate from their mature differentiated state to a dedifferentiated state. BRD4 plays a pivotal role during embryogenesis and cancer development, but its function in modulating β-cell differentiation remains unknown. In this study, multiple models including calorie restriction …

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Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing

Yujing Sun, Zhenhua Zhang, Qincheng Qiao, Ying Zou et autres

The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to decipher the immunometabolic profile in 4 ME/CFS …

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Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance

Chaojia Chen, Fangcheng Zhao, Jiali Peng, Di Zhao et autres

Resistance to PD-1 blockade in onco-immunotherapy greatly limits its clinical application. T cell immunoglobulin and mucin domain containing-3 (Tim-3), a promising immune checkpoint target, is cleaved by ADAM10/17 to produce its soluble form (sTim-3) in humans, potentially becoming involved in anti-PD-1 resistance. …

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Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy

Rong Xiao, Ye Tian, Jiwei Zhang, Na Li et autres

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Injectable thermosensitive selenium-containing hydrogel as mesenchymal stem cell carrier to improve treatment efficiency in limb ischemia

Xuan Tian, Xin Yan, Nan Zang, Duan Wu et autres

Limb ischemia is a refractory disease characterized by persistent inflammation, insufficient angiogenesis, and tissue necrosis. Although mesenchymal stem cells (MSCs) have shown potential for treating limb ischemia, their therapeutic effects are limited by low engraftment rates. Therefore, developing an optimal MSC delivery …

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ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury

Yankun Zhang, Yu‐Chen Fan, Huili Hu, Xiaohui Zhang et autres

Mitochondria dysfunction contributes to acute liver injuries, and mitochondrial regulators, such as PGC-1α and MCJ, affect liver regeneration. Therefore, identification of mitochondrial modulators may pave the way for developing therapeutic strategies. Here, ZHX2 is identified as a mitochondrial regulator during acute liver …

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The hepatic GABAergic system promotes liver macrophage M2 polarization and mediates HBV replication in mice

Ziyou Bao, Xiaotong Chen, Yan Li, Wenshan Jiang et autres

Macrophages display functional phenotypic plasticity. Hepatitis B virus (HBV) infection induces polarizations of liver macrophages either to M1-like pro-inflammatory phenotype or to M2-like anti-inflammatory phenotype. Gamma-aminobutyric acid (GABA) signaling exists in various non-neuronal cells including hepatocytes and some immune cells. Here we …

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TIPE1 promotes liver regeneration by enhancing ROS‐FoxO1 axis mediated autophagy

Xiaodong Zhang, Shuangjie Li, Xiaolei Ren, Xiang Peng et autres

The strong regenerative ability of the liver safeguards the crucial hepatic functions. The balance between hepatocyte proliferation and death is critical for restoring liver size and physiology. Tumour necrosis factor (TNF) alpha-induced protein 8-like 1 (TIPE1) is highly expressed in liver and …

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Author response for " TIPE1 promotes liver regeneration by enhancing ROS‐FoxO1 axis mediated autophagy"

Xiaodong Zhang, Shuangjie Li, Xiaolei Ren, Xiang Peng et autres

CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer

Xiaojia Song, Na Li, Yuan Liu, Zehua Wang et autres

Radiofrequency ablation (RFA) is a widely used and effective treatment for primary or metastatic liver cancer with small-size lesions. However, the therapeutic effectiveness of RFA in controlling metastatic lesion or recurrence is still limited. As the major cell population in tumor microenvironment …

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