Accès ouvert
2026
article
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, Feng Ju et autres
BACKGROUND: Therapeutic resistance in esophageal adenocarcinoma (EAC) remains poorly understood at the level of tumor-stroma interactions. We investigated whether cancer-associated fibroblast (CAF)-derived signaling contributes to chemoradiation resistance and adverse clinical outcomes in EAC, with a focus on the functional role of GDF15 …
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, Feng Ju et autres
Supplementary Material 1.
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, J. Feng et autres
Abstract Background Therapeutic resistance in esophageal adenocarcinoma (EAC) remains poorly understood at the level of tumor-stroma interactions. We investigated whether cancer-associated fibroblast (CAF)-derived signaling contributes to chemoradiation resistance and adverse clinical outcomes in EAC, with a focus on the functional role of …
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, Feng Ju et autres
Supplementary Material 1.
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, J. Feng et autres
Abstract Background Therapeutic resistance in esophageal adenocarcinoma (EAC) remains poorly understood at the level of tumor-stroma interactions. We investigated whether cancer-associated fibroblast (CAF)-derived signaling contributes to chemoradiation resistance and adverse clinical outcomes in EAC, with a focus on the functional role of …
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Sascha Hoppe, Soha Noseir, Ali M. Yazbeck, Nestor Zaburannyi et autres
Summary Neoadjuvant chemoradiation therapy (RCT) is a frequently used treatment regimen for esophageal adenocarcinoma (EAC); however, the response varies dramatically, and resistance is a clinical challenge. We aimed to identify the molecular mechanisms underlying RCT resistance. We established a mouse xenograft RCT …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Patrick Sven Plum, Timo Hess, Denis Bertrand, Isabelle Morgenstern et autres
BACKGROUND: Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Environmental factors may contribute to regional differences …
de, sg, ro, ch
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Philipp Müller, Oscar Velázquez Camacho, Ali M. Yazbeck, Christina B. Wölwer et autres
Loss of the Y chromosome (LoY) is frequently observed in somatic cells of elderly men. However, LoY is highly increased in tumor tissue and correlates with an overall worse prognosis. The underlying causes and downstream effects of LoY are widely unknown. Therefore, …
de, cn
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Jiahui Li, Xiao‐Lin Wu, Lars Mortimer Schiffmann, Thomas MacVicar et autres
In pancreatic ductal adenocarcinoma (PDAC), the tumor stroma constitutes most of the cell mass and contributes to therapy resistance and progression. Here we show a hitherto unknown metabolic cooperation between pancreatic stellate cells (PSCs) and tumor cells through Interleukin 17B/Interleukin 17B receptor …
de, cn, se
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Sascha Hoppe, Christoph Jonas, Marten C Wenzel, Oscar Velázquez Camacho et autres
Esophageal adenocarcinoma (EAC) is a deadly disease with limited options for targeted therapy. With the help of next-generation sequencing studies over the last decade, we gained an understanding of the genomic architecture of EAC. The tumor suppressor gene TP53 is mutated in …
de
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Martin Thelen, Kerstin Wennhold, Jonas M. Lehmann, Maria Alejandra Garcia-Marquez et autres
The immune response against cancer is orchestrated by various parameters and site-dependent specificities have been poorly investigated. In our analyses of ten different cancer types, we describe elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets …
de
(code pays fourni par la source)
2021
article
OpenAlex
Martha Kiljan, Oscar Velázquez Camacho, Meryem Seda Ercanoglu, Isabelle Heßelmann et autres
As a key player of the adaptive immune system CD4+ T cells play a critical role in orchestrating an effective immune response during infections, autoimmunity or cancer. Few studies have addressed antigen‐mediated reactivation of T effector cells in peripheral tissues, as opposed …
de, sk, se
(code pays fourni par la source)