Accès ouvert
2026
article
OpenAlex
Zhefang Wang, Qiu Huang, Jiangang Zhao, Zicheng Lyu et autres
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy due to its aggressive biology and therapeutic resistance. Lysine-specific demethylase 1 (LSD1), an epigenetic regulator, is overexpressed in PDAC and linked to poor prognosis, yet its context-dependent roles in metabolic subtypes and chemoresistance …
de, cn
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Accès ouvert
2026
article
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, Feng Ju et autres
BACKGROUND: Therapeutic resistance in esophageal adenocarcinoma (EAC) remains poorly understood at the level of tumor-stroma interactions. We investigated whether cancer-associated fibroblast (CAF)-derived signaling contributes to chemoradiation resistance and adverse clinical outcomes in EAC, with a focus on the functional role of GDF15 …
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, Feng Ju et autres
Supplementary Material 1.
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, J. Feng et autres
Abstract Background Therapeutic resistance in esophageal adenocarcinoma (EAC) remains poorly understood at the level of tumor-stroma interactions. We investigated whether cancer-associated fibroblast (CAF)-derived signaling contributes to chemoradiation resistance and adverse clinical outcomes in EAC, with a focus on the functional role of …
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, Feng Ju et autres
Supplementary Material 1.
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Ningbo Fan, Pinwei Deng, Zhefang Wang, J. Feng et autres
Abstract Background Therapeutic resistance in esophageal adenocarcinoma (EAC) remains poorly understood at the level of tumor-stroma interactions. We investigated whether cancer-associated fibroblast (CAF)-derived signaling contributes to chemoradiation resistance and adverse clinical outcomes in EAC, with a focus on the functional role of …
cn, de, nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Qi Bao, Jie Pan, Zhefang Wang
Introduction: Immune checkpoint inhibitors (ICIs) targeting PD-1 have revolutionized melanoma treatment, yet their clinical efficacy is frequently limited by immune-related adverse events (irAEs). The underlying mechanisms of irAEs remain poorly defined, particularly in the acral melanoma subtype. Methods: To identify peripheral immune …
cn
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Accès ouvert
2026
article
OpenAlex
Zhefang Wang, Zicheng Lyu, Raphael Palmen, Qi Bao et autres
Pancreatic ductal adenocarcinoma (PDAC) presents significant treatment challenges, primarily due to its propensity for developing resistance to therapeutic interventions. While the underlying mechanisms remain elusive, they are closely associated with mitochondrial adaptation in response to treatment. Mitophagy, a selective subtype of autophagy …
de, cn
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Accès ouvert
2025
article
OpenAlex
Feng Ju, Jialei Weng, Ningbo Fan, Zhefang Wang et autres
Esophageal adenocarcinoma (EAC) is the predominant subtype of esophageal cancer (EC) in high-income countries, and radioresistance is one of the key factors for the poor prognosis. In this study, we successfully established a radioresistant EAC in vitro model. Aldo-keto reductase 1C3 (AKR1C3) …
de, cn
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Accès ouvert
2025
article
OpenAlex
Tian Xia, Haimeng Yin, Qingwen Zhu, Kaiwen Zhang et autres
Anti-angiogenic therapies (AATs) exhibit limited efficacy, as most patients with cancer inevitably develop resistance to them. In this study, data generated using a nasopharyngeal carcinoma orthotopic mouse model, combined with clinical data, reveal compensatory vasculogenic mimicry (VM) formation during AAT treatment and …
cn
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Accès ouvert
2025
article
OpenAlex
Siyu Zhang, Miao Gu, Haimeng Yin, Si Pan et autres
Autophagy is associated with chemoresistance, which is the leading cause of failure in chemotherapeutic treatments. Among the various aspects of autophagy, autophagic flux serves as a critical indicator for evaluating the dynamic processes involved.We report herein that the multifunctional protein HAX-1 promotes …
cn, de
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Accès ouvert
2023
article
OpenAlex
Qu Jiang, Johanna Stachelscheid, Johannes Bloehdorn, Alicja Pacholewska et autres
In chronic lymphocytic leukemia (CLL), epigenetic alterations are considered to centrally shape the transcriptional signatures that drive disease evolution and underlie its biological and clinical subsets. Characterizations of epigenetic regulators, particularly histone-modifying enzymes, are very rudimentary in CLL. In efforts to establish …
de, us, cn, au
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