Accès ouvert
2026
article
OpenAlex
Armin Scheffler, Paolina Krois, Martha Kiljan, Christoph Kleinschnitz et autres
Aim Calcitonin gene-related peptide (CGRP) plays a key role in migraine and is also known for its immunomodulatory properties. When released from neurons, CGRP can induce T-cell exhaustion markers, such as T-cell immunoglobulin and mucin-domain containing-3 (TIM3) and programmed cell death protein …
de, se
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Accès ouvert
2025
article
OpenAlex
France Rose, Olta Ibruli, Luca Lichius, Martha Kiljan et autres
OBJECTIVES: Small cell lung cancer (SCLC) accounts for approximately 15% of lung tumors and is marked by aggressive growth and early metastatic spread. In this study, we used two SCLC mouse models with differing tumor mutation burdens (TMB). To investigate tumor composition, …
de
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Accès ouvert
2024
article
OpenAlex
Olta Ibruli, France Rose, Filippo Beleggia, Anna Schmitt et autres
PURPOSE: Small cell lung cancer (SCLC) has an extremely poor prognosis. Despite high initial response rates to chemotherapy and modest survival improvements with the addition of immune checkpoint inhibitors (ICI), almost all patients experience relapse and fatal outcomes. Recent genomic insights uncovered …
de, gb
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Accès ouvert
2024
article
OpenAlex
Mario Zierden, Eva Maria Berghausen, Leoni Gnatzy-Feik, Christopher Millarg et autres
Chronic activation of the adaptive immune system is a hallmark of atherosclerosis. As PI3Kδ is a key regulator of T and B cell differentiation and function, we hypothesized that alleviation of adaptive immunity by PI3Kδ inactivation may represent an attractive strategy counteracting …
de, us, hu
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2024
article
OpenAlex
Mario Zierden, Eva Maria Berghausen, Leoni Gnatzy-Feik, Christopher Millarg et autres
Abstract Introduction and Purpose Atherosclerosis is a chronic inflammatory disease of arteries, critically involving innate and adaptive immune cells like macrophages as well as T and B lymphocytes. Macrophages are major drivers of disease through the ingestion of lipoproteins, foam cell formation, …
de
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Accès ouvert
2023
preprint
OpenAlex
Pascal Hunold, Michaela Nicole Hoehne, Martha Kiljan, Olivia van Ray et autres
Abstract Breast cancer is characterised by genetic and epigenetic alterations, such as G-quadruplex (G4) DNA secondary structures. Here, we uncover differentially enriched G4 structure-forming regions (∆G4Rs) and interlinked transcriptomes in the tumour microenvironment (TME) of breast cancer PDX models in vivo . …
de, us
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Accès ouvert
2021
article
OpenAlex
Martha Kiljan, Sabrina Weil, Andrés Vásquez-Torres, Meike Hettich et autres
PURPOSE: Radiation therapy (RT) is a common nonsurgical treatment in the management of patients with cancer. While genetically engineered mouse models (GEMM) recapitulate human disease, conventional linear particle accelerator systems are not suited for state-of-the-art, imageguided targeted RT (IGRT) of these murine …
de
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2021
article
OpenAlex
Elena Wagner, Lina Niu, Martha Kiljan, Olta Ibruli et autres
The adjunction of PD‐1/PD‐L1 immunotherapy and radiation therapy (RT) has proven to be an effective approach to combat cancer. Clinical studies recently confirmed that patients show increased response to immune checkpoint inhibitors if also treated with RT. One effect of RT in …
de
(code pays fourni par la source)
2021
article
OpenAlex
Isabelle Heßelmann, Matthias Reinscheid, Martha Kiljan, Lina Niu et autres
Even though immunotherapy is a common part in cancer treatment, only a small subset of patients profits long term. Since radiation therapy (RT) has been shown to improve tumor immunogenicity, treatment strategies combining RT and immunotherapy are an emerging field in cancer …
de
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2021
article
OpenAlex
Martha Kiljan, Oscar Velázquez Camacho, Meryem Seda Ercanoglu, Isabelle Heßelmann et autres
As a key player of the adaptive immune system CD4+ T cells play a critical role in orchestrating an effective immune response during infections, autoimmunity or cancer. Few studies have addressed antigen‐mediated reactivation of T effector cells in peripheral tissues, as opposed …
de, sk, se
(code pays fourni par la source)
2020
conference-abstract
OpenAlex
Martha Kiljan, Sabrina Weil, Matthias Reinscheid, Olta Ibruli et autres
The synergy of modern immunotherapeutics and radiation has proven to be a promising strategy to combat cancer. However, fundamental questions regarding the underlying mechanisms of these therapies are unanswered. While clinical studies have demonstrated that radiation can potentially boost immune cell infiltration …
de
(code pays fourni par la source)
2020
conference-abstract
OpenAlex
Sabrina Weil, Martha Kiljan, Andrés Vásquez-Torres, Meike Hettich et autres
Cancer remains to be a leading cause of death worldwide, accounting for almost 10 million deaths in 2018. Radiation therapy (RT) is a common nonsurgical treatment in the management of patients with cancer that reduces disease recurrence and improves overall survival. However, …
de
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