J. Dittmann

Enhanced Anti-Amyloid Effect of Combined Leptin and Pioglitazone in APP/PS1 Transgenic Mice

Yao Liu, Kelsey Hanson, Graeme H. McCormack, Rachel A.K. Atkinson et autres

BACKGROUND: Alzheimer's disease (AD) has challenged single-target therapeutic strategies, raising the possibility that combined therapies may offer a more effective treatment strategy. OBJECTIVE: There is substantial evidence for the efficacy of leptin (L) (neuroprotective hormone) and pioglitazone (P) (anti-inflammatory agent) as monotherapies …

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Enhanced anti-amyloid effect of combined leptin and pioglitazone in APP/PS1 transgenic mice

Yao Liu, Kelsey Hanson, Graeme H. McCormack, J. Dittmann et autres

ABSTRACT Background Alzheimer’s disease (AD) has challenged single-target therapeutic strategies, raising the possibility that combined therapies may offer a more effective treatment strategy. Objective There is substantial evidence for the efficacy of leptin (L) (neuroprotective hormone) and pioglitazone (P) (anti-inflammatory agent) as …

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Disruption of leptin signalling in a mouse model of Alzheimer’s disease

Anna E. King, Anna Brain, Kelsey Hanson, J. Dittmann et autres

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Mid‐life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ‐associated pathology and positively influences synaptic and cognitive health in healthy ageing

Kimberley E. Stuart, Anna E. King, CM Fernandez-Martos, J. Dittmann et autres

Abstract Early‐life cognitive enrichment may reduce the risk of experiencing cognitive deterioration and dementia in later‐life. However, an intervention to prevent or delay dementia is likely to be taken up in mid to later‐life. Hence, we investigated the effects of environmental enrichment …

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Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog

Marilyn Ader, Darko Stefanovski, Stella P. Kim, Joyce M. Richey et autres

OBJECTIVE: Insulin resistance is a powerful risk factor for Type 2 diabetes and a constellation of chronic diseases, and is most commonly associated with obesity. We examined if factors other than obesity are more substantial predictors of insulin sensitivity under baseline, nonstimulated …

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Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol

Anna E. King, Katherine A. Southam, J. Dittmann, James C. Vickers

BACKGROUND: Axon degeneration, a key pathological event in many neurodegenerative diseases and injury, can be induced by somatodendritic excitotoxin exposure. It is currently unclear, however, whether excitotoxin-induced axon degeneration is mechanistically similar to Wallerian degeneration, which occurs following axon transection, but does …

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Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways

Y. K. Leung, Michaël W. Pankhurst, Sarah A. Dunlop, Shannon Ray et autres

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Redefining the Role of Metallothionein within the Injured Brain

Roger S. Chung, Milena Penkowa, J. Dittmann, Carolyn King et autres

A number of intracellular proteins that are protective after brain injury are classically thought to exert their effect within the expressing cell. The astrocytic metallothioneins (MT) are one example and are thought to act via intracellular free radical scavenging and heavy metal …

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Contents, Vol. 6, 1971 / Foreword

J.N. Barker, J.C. de Valois, J.P.C. Peperkamp, J.P. Schadé et autres

Respiration, Aerobic Glycolysis and Swelling of Normal and Edematous Rabbit Brain Slices at Different O 2 and CO 2 Partial Pressures

J. Dittmann, H. -D. Herrmann

Research Articles| January 24 2008 Respiration, Aerobic Glycolysis and Swelling of Normal and Edematous Rabbit Brain Slices at Different O2and CO2 Partial Pressures Subject Area: Neurology and Neuroscience J. Dittmann; J. Dittmann Neurosurgery University Hospital, Homburg/Saar Search for other works by this …

RedefiningtheRoleofMetallothioneinwithintheInjuredBrain EXTRACELLULARMETALLOTHIONEINSPLAYANIMPORTANTROLEINTHE ASTROCYTE-NEURONRESPONSETOINJURY *

Roger S. Chung, Milena Penkowa, J. Dittmann, Carolyn King et autres

A number of intracellular proteins that are protective after brain injury are classically thought to exert their effect within the expressing cell. The astrocytic metallothioneins (MT) are one example and are thought to act via intracellular free radical scavenging and heavy metal …

[P202]: Interactions between metallothionein and cortical neurons in vitro

Samantha J. Fung, J. Dittmann, M.I. Chuah, Roger S. Chung et autres

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