Michaël W. Pankhurst

Single-oocyte mRNA sequencing reveals that AMH-overexpression alters oocyte gene expression

Timothy A. Hore, Michaël W. Pankhurst

CONTEXT: Anti-Müllerian hormone (AMH) regulates ovarian follicle development, but AMH overexpression has been linked to impaired fertility and pregnancy failure. Our previous studies indicated that AMH overexpression hindered preimplantation embryo development. AIMS: To investigate whether AMH influences oocyte competence, we performed single-oocyte …

nz (code pays fourni par la source)

The elusive function of AMH signaling in folliculogenesis

Michaël W. Pankhurst

nz (code pays fourni par la source)

Is preovulatory follicle selection influenced by the production of oocyte-secreted factors?

Nicholas J. Anderson, Michaël W. Pankhurst

The mammalian ovary ovulates only a fraction of the oocytes it produces, as more than 99% are discarded during development. Females devote a large amount of energy to pregnancy, lactation and subsequent parental care, hence there is strong imperative to produce highly …

nz (code pays fourni par la source)

Transient variation in anti-Müllerian hormone concentrations with repeat testing in a fertility clinic setting

Bridie Lewry, John Peek, Dean E. Morbeck, Michaël W. Pankhurst

RESEARCH QUESTION: Is it possible for a patient to have low anti-Müllerian hormone (AMH) readings that recover to normal concentrations over the space of months or 1-2 years? DESIGN: This was a retrospective analysis of a fertility clinic patient database. Patients with …

nz (code pays fourni par la source)

AMH regulates ovary size by counteracting ovarian follicle cluster effects.

Carmen Lim, Lynn Yiew, Nicholas J. Anderson, Peter R. Smith et autres

Serum anti-Mullerian hormone (AMH) is the primary clinical indicator of mature oocyte counts in the ovaries, but its biological role remains poorly understood. Mammalian ovaries have a finite lifetime of oocytes that are slowly depleted as the dormant follicles housing the oocytes …

nz, au (code pays fourni par la source)

#228 : Variability of Symptom Profiles in Individuals with Mate Kirikoopu/Endometriosis and/or Huahua Hua Kuao/Polycystic Ovary Syndrome in Aotearoa New Zealand

Jamie Salemink-Waldren, Zachary Adamson, Deborah Bush, Rebecca E. Campbell et autres

Background and Aims: Although opposing risk factors have been proposed for mate kirikōpū/endometriosis (oestrogen-dependence) and huahua hua kūao/polycystic ovary syndrome (PCOS; androgen dependence), there is a cohort of individuals with both endometriosis and PCOS. We propose that disease comorbidity will alter symptom …

Ovarian follicle size or growth rate can both be determinants of ovulatory follicle selection in mice

Sharon Richard, Yiran Zhou, Christine L. Jasoni, Michaël W. Pankhurst

The endocrinology regulating ovulation of the desired number of oocytes in the ovarian cycle is well described, particularly in mono-ovulatory species. Less is known about the characteristics that make one follicle suitable for ovulation while most other follicles die by atresia. Bromodeoxyuridine …

nz (code pays fourni par la source)

Mouse primary follicles experience slow growth rates after activation and progressive increases that influence the duration of the primary follicle phase

Sharon Richard, Nicholas J. Anderson, Yiran Zhou, Michaël W. Pankhurst

There are conflicting estimates of the duration of mouse primary follicle development. An accurate determination is needed for studies examining preantral follicle survival and mathematical modeling of folliculogenesis. Primary follicle granulosa cell proliferation rates are low and variable, which may explain the …

nz (code pays fourni par la source)

Serum Anti-Müllerian Hormone Is an Effective Indicator of Antral Follicle Counts but Not Primordial Follicle Counts

Yiran Zhou, Kate L Scott, E.M. Quin, Michaël W. Pankhurst

Serum anti-Müllerian hormone (AMH) is a biomarker for predicting antral follicle counts but there is no clear consensus on whether AMH is indicative of primordial follicle counts in humans. Mice were used as a model species in this study to obtain accurate …

nz (code pays fourni par la source)

Anti-Müllerian hormone-mediated preantral follicle atresia is a key determinant of antral follicle count in mice

Yiran Zhou, Sharon Richard, Nicola J Batchelor, Dorothy E. Oorschot et autres

STUDY QUESTION: Does anti-Müllerian hormone (AMH) induce preantral follicle atresia in mice? SUMMARY ANSWER: The present findings suggest that AMH-mediated follicle atresia only occurs in early follicles before they become sensitive to FSH. WHAT IS KNOWN ALREADY: Most prior studies have investigated …

nz (code pays fourni par la source)

Key signalling pathways underlying the aetiology of polycystic ovary syndrome

Kirsty A. Walters, Nigel K. Stepto, Michaël W. Pankhurst, Raymond J. Rodgers

Polycystic ovary syndrome (PCOS) is a common endocrine condition characterised by a range of reproductive, endocrine, metabolic and psychological abnormalities. Reports estimate that around 10% of women of reproductive age are affected by PCOS, representing a significant prevalence worldwide, which poses a …

au, nz (code pays fourni par la source)

Proteolytic activation of anti-Müllerian hormone is suppressed in adolescent girls

Michaël W. Pankhurst, Peter W. Dillingham, Alexia Peña

nz, au (code pays fourni par la source)