S. S. Yang

Mindfulness and Existential Healing Interventions in Palliative Care for Patients with Advanced Cancer:A Scoping Review

S. S. Yang, Yan Lou, Tingting chen, Tongling Liu et autres

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A Noddings’ caring theory-based intervention to enhance coping with death competence in advanced lung cancer patients: a randomized controlled trial

Jing Li, Huang Runqin, Xian Luo, YongJia Zhan et autres

PURPOSE: This randomized controlled trial aimed to evaluate the effects of a Noddings' caring theory-based intervention on coping with death competence (CDC), death attitudes, and psychological distress in patients with advanced lung cancer. METHODS: Seventy inpatients were randomly allocated to the intervention …

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The Chinese version of the autonomy preference index for advanced cancer patients: a study on cultural adaptation based on cognitive interview

Chao Yan, Yonghong Li, ji ai, S. S. Yang

BACKGROUND: The global cancer burden is becoming increasingly severe. In the context of patient-centred medicine, respecting patients' autonomy and preferences is of paramount importance. However, there is currently a lack of scientific tools in China to measure the autonomous preferences of advanced …

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The death education needs of patients with advanced cancer: a qualitative research

S. S. Yang, Chao Yan, Jing Li, Yinglu Feng et autres

BACKGROUND: Cancer remains a global health concern, with nearly 20 million new cancer cases and approximately 10 million cancer-related deaths reported in 2020.An increasing number of individuals with advanced-stage cancer are likely to confront the reality of mortality.In China, cancer-related deaths hold …

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ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer

Paloma Moreno, Yuuki Ohara, Amanda J. Craig, Huaitian Liu et autres

Pancreatic ductal adenocarcinoma (PDAC) manifests diverse molecular subtypes, including the classical/progenitor and basal-like/squamous subtypes, with the latter known for its aggressiveness. We employed integrative transcriptome and metabolome analyses to identify potential genes contributing to the molecular subtype differentiation and its metabolic features. …

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MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways

S. S. Yang, Wei Tang, Azadeh Azizian, Jochen Gaedcke et autres

Inflammation and aberrant cellular metabolism are widely recognized as hallmarks of cancer. In pancreatic ductal adenocarcinoma (PDAC), inflammatory signaling and metabolic reprogramming are tightly interwoven, playing pivotal roles in the pathogenesis and progression of the disease. However, the regulatory functions of inflammatory …

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LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism

Yuuki Ohara, Amanda J. Craig, Huaitian Liu, S. S. Yang et autres

Pancreatic ductal adenocarcinoma (PDAC) encompasses diverse molecular subtypes, including the classical/progenitor and basal-like/squamous subtypes, each exhibiting distinct characteristics, with the latter known for its aggressiveness. We employed an integrative approach combining transcriptome and metabolome analyses to pinpoint potential genes contributing to the …

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Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates

Robert W. Buckheit, M Snow, Valerie Fliakas-Boltz, T L Kinjerski et autres

The structure-activity relationships of a series of compounds related to the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) oxathiin carboxanilide have been described (R. W. Buckheit, Jr., T. L. Kinjerski, V. Fliakas-Boltz, J. D. Russell, T. L. Stup, L. A. Pallansch, W. G. …

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A Diarylsulphone Non-Nucleoside Reverse Transcriptase Inhibitor with a Unique Sensitivity Profile to Drug-Resistant Virus Isolates

Robert W. Buckheit, Valerie Fliakas-Boltz, J D Russell, M Snow et autres

Structure-activity relationship evaluations with a series of diarylsulphone non-nucleoside reverse transcriptase (RT) inhibitors indicated that the steric properties of the molecule and compound lipophilicity primarily contributed to the overall level of activity of the compounds against human immunodeficiency virus type 1 (HIV-1). …

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The NCI's AIDS antiviral drug screening program.

S. S. Yang

The Developmental Therapeutics Program (DTP) in the National Cancer Institute has an unique mission by serving as a resource for all academic and private research institutions, the National Institutes of Health in the USA, and the global scientific community in the quest …

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A human hepatocellular carcinoma 3.0-kilobase DNA sequence transforms both rat liver cells and NIH3T3 fibroblasts and encodes a 52-kilodalton protein.

S. S. Yang, Kunbo Zhang, William Viera, Janet Taub et autres

Neoplastic transformation of rat liver cells in vitro by DNA-mediated gene transfer with an oncogene, hhcM, derived from human (Mahlavu) hepatocellular carcinoma, is described and compared with that of NIH3T3 cells. hhcM was cloned in a neomycin-resistant simian virus 40 promoter vector …

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Dose dependency of aflatoxin B1 binding on human high molecular weight DNA in the activation of proto-oncogene.

S. S. Yang, Janet Taub, Ramakrishna V. Modali, W Vieira et autres

The binding of aflatoxin B1, AFB1, a potent hepatocarcinogen, to various high molecular weight (HMW) DNAs from human normal liver and two liver cancer cell lines, Alexander primary liver carcinoma (PLC) and Mahlavu hepatocellular carcinoma (hHC) and from NIH/3T3 cell have been …