Phillip Demarest

Right amygdala ablation reduces maladaptive negative interpretation bias and symptoms in a patient with post-traumatic stress disorder

Tao Xie, Sanne J.H. van Rooij, Sai Sun, Noah Bryson et autres

Negative interpretation bias - the tendency to perceive ambiguous stimuli as threatening - is a core cognitive distortion underlying post-traumatic stress disorder (PTSD). The amygdala, a key structure in fear processing, is implicated in PTSD-related hypervigilance and heightened fear perception, yet direct …

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A transposase-derived gene required for human brain development

Luz Jubierre Zapater, Sara A. Lewis, Rodrigo Lopez Gutierrez, Makiko Yamada et autres

Vertebrate brain development is associated with prominent neuronal cell death and DNA breaks, but their causes and functions are not well understood. DNA transposable elements could contribute to somatic genome rearrangements; however, their contributions to brain development are largely unknown. PiggyBac transposable …

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Improving Neurotechnologies for Chronic Pain through Brain-Computer Interfaces and Invasive Models of Human Cingulate Cortex Networks.

Phillip Demarest

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Mind’s eye: widespread saccade-related evoked potentials support visual memory encoding in humans

Gansheng Tan, Phillip Demarest, Yilin Li, Hohyun Cho et autres

In active vision, the brain receives and encodes discontinuous streams of visual information gated by saccadic eye movements. Saccadic modulation of neural activity is hypothesized to evolve to support perception and memory; however, it remains unclear whether this mechanism exist in humans, …

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Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas

Yaniv Kazansky, Helen S. Mueller, Daniel Cameron, Phillip Demarest et autres

Despite the potential of targeted epigenetic therapies, most cancers do not respond to current epigenetic drugs. The polycomb repressive complex EZH2 inhibitor tazemetostat was recently approved for the treatment of SMARCB1-deficient epithelioid sarcomas, based on the functional antagonism between PRC2 and SMARCB1. …

Cortical spectral dynamics of vibrotactile frequency processing

Nabi Rustamov, Phillip Demarest, Zhuangyu Han, Safia Mohamud et autres

While scientific research has extensively explored how the brain integrates touch and pain signals, the cerebral processing of specific vibrotactile frequencies remains poorly understood. This gap is particularly significant given clinical evidence that vibrotactile stimulation can reduce pain in both chronic pain …

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Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas

Yaniv Kazansky, Helen S. Mueller, Daniel Cameron, Phillip Demarest et autres

Despite the potential of targeted epigenetic therapies, most cancers do not respond to current epigenetic drugs. The polycomb repressive complex EZH2 inhibitor tazemetostat was recently approved for the treatment of SMARCB1-deficient epithelioid sarcomas, based on the functional antagonism between PRC2 and SMARCB1. …

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Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study

Kara M Donovan, Josh Adams, Ki Yun Park, Phillip Demarest et autres

Vibration offers a potential alternative modality for transcutaneous auricular vagus nerve stimulation (taVNS). However, mechanisms of action are not well-defined. The goal of this pilot study was to evaluate the potential of vibrotactile stimulation of the outer ear as a method for …

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Cortical Spectral Dynamics of Vibrotactile Frequency Processing

Nabi Rustamov, Phillip Demarest, Zhuangyu Han, Safia Mohamud et autres

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Author response: The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial

Gansheng Tan, Anna L. Huguenard, Kara M Donovan, Phillip Demarest et autres

The authors provide a solid set of data supporting the safety of transcutaneous auricular vagal nerve stimulation on cardiovascular parameters in the acute setting of critically ill patients presenting with subarachnoid hemorrhage.This important study also suggests a promising effect on autonomic balance.

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Exploring individual differences in amygdala-mediated memory modulation

Martina K. Hollearn, Joseph R. Manns, Lou T. Blanpain, Stephan B. Hamann et autres

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The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial

Gansheng Tan, Anna L. Huguenard, Kara M Donovan, Phillip Demarest et autres

Background: Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) and its ability to promote brain plasticity, taVNS has …

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