Junyi Jiang

Artificial intelligence in diabetes care: from predictive analytics to generative AI and implementation challenges

Mengqi Deng, Ruiye Yang, Xiaoran Zheng, Junyi Jiang

Generative artificial intelligence (GenAI) is transforming public health and medicine as well, in the form of disease surveillance, resource allocation and clinical decision making. Interventions to improve efficiency - multimodal predictive algorithms, federated learning platforms - reveal the internal contradictions of the …

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B7-H3-mediated reversal of CAR-T cell exhaustion induces a notable antitumour response in ovarian cancer models

Qun Liu, Mengqi Deng, Junyi Jiang, Fan Tang et autres

BACKGROUND: Functional CAR-T cell exhaustion in the immunosuppressive tumour microenvironment remains the main barrier to the success of CAR-T cell therapy for treating solid tumours. Mesothelin (MSLN) has emerged as an attractive target for CAR-T cell therapy for several solid malignancies, including …

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The silent spread: exploring diverse metastatic pathways in high-grade serous ovarian cancer

Mengqi Deng, Ruiye Yang, Junyi Jiang, Jinxu Zhang et autres

High-grade serous ovarian cancer (HGSOC) is a highly aggressive and deadly gynecological cancer, with metastasis being a key factor in its poor prognosis. Historically, HGSOC was thought to spread primarily through the peritoneal cavity, but recent research has revealed additional routes of …

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Author Correction: A targetable OSGIN1–AMPK–SLC2A3 axis controls the vulnerability of ovarian cancer to ferroptosis

Mengqi Deng, Fan Tang, Xiangyu Chang, Yanqin Zhang et autres

In the original version of this article, Figs. 7 and 8 are missing scale bars. The original article has been corrected to include the appropriate scale bars in Figs. 7 and 8.

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A targetable OSGIN1 − AMPK − SLC2A3 axis controls the vulnerability of ovarian cancer to ferroptosis

Mengqi Deng, Fan Tang, Xiangyu Chang, Yanqin Zhang et autres

Despite advances in various chemotherapy regimens, current therapeutic options are limited for ovarian cancer patients. Oxidative stress-induced growth inhibitor 1 (OSGIN1), which is a tumor suppressor gene known to regulate the cellular stress response and apoptosis, is associated with ovarian cancer development. …

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Pharmacokinetics, pharmacodynamics, and tolerability of JY09 in healthy Chinese subjects: A titrating, dose-escalating study

Guang‐Yu Yang, Bei Cao, Yuanxun Yang, Yan Geng et autres

OBJECTIVES: To evaluate the pharmacokinetics, pharmacodynamics, and tolerability of JY09, a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist, in healthy subjects. MATERIALS AND METHODS: Healthy subjects were enrolled into 5 cohorts (0.3, 0.7, 1.5, 3.0, and 6.0 mg JY09) and received subcutaneous JY09 …

効用分析による共著者ネットワークの形成の解釈【Powered by NICT】

Yongli Li, Dong Zhang, Peng Luo, Junyi Jiang

Quantitative determination of rhein in human plasma by liquid chromatography–negative electrospray ionization tandem mass/mass spectrometry and the application in a pharmacokinetic study

Junyi Jiang, Mingwei Yang, Weijun Qian, Hui Yen Lin et autres

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Evaluation of quality control for therapeutic drug monitoring of tacrolimus by enzyme-multiplied immunoassay technique

Junyi Jiang

Objective:To evaluate the quality of enzyme-multiplied immunoassay technique(EMIT) for therapeutic drug monitoring(TDM) of tacrolimus,establish and improve the quality control method for TDM of tacrolimus.Methods:Researches on prospective and internal quality control were carried out on standard quality control samples.Results of TDM of control …

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Advancements of drug treatment for infection of mycoplasma pneumoniae in children

Junyi Jiang

Mycoplasma pneumoniae is one of the main etiologic agents of respiratory tract infection in children.In recent years, the annual specifi c incidence rate of mycoplasma pneumoniae infection of children especially among infants has been greatly increasing.Comprehensive measures are necessary to the treatments …

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HPLC-FLD法を用いて,肺組織におけるエステル型とヒドロキシカンプトテシンの含有量を測定した。【JST・京大機械翻訳】

Junyi Jiang, Yun Fang, Zhang Haixia

Determination of the Total Flavonoids in Ainsliaea fragrans Champ by Spectrophotometric Method

Junyi Jiang

Objective:To establish a method for the determination of the total flavonoids in Ainsliaea fragrans Champ.Methods:The total flavonoids in Ainsliaea fragrans Champ was determined by spectrophotometric method at 500 nm.Results:Sample size showed a good linear, relationship at the range of 8.08～48.48 μg/ml, r=0.999 …