Accès ouvert
2026
article
OpenAlex
Marit Stockfelt, Henri A. J. Puttonen, Ing‐Marie Fyhr, Agnes Torell et autres
BACKGROUND: Although systemic lupus erythematosus (SLE) pregnancy frequently results in small for gestational age (SGA) infants, the understanding of underlying mechanisms is limited. We aimed to identify specific histological patterns of placental injury in SGA in SLE and to explore whether an …
se, fi, no
(code pays fourni par la source)
Accès ouvert
2026
conference-paper
OpenAlex
Anna‐Carin Lundell, Agnes Torell, Kerstin Andersson, Iva Gunnarsson et autres
Objectives OBJECTIVE: Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with systemic lupus erythematosus (SLE). Although disease activity and autoantibodies such as anti-Smith and anti-RNP associate with SGA, underlying pathological mechanisms remain unclear and …
se
(code pays fourni par la source)
Accès ouvert
2026
conference-paper
OpenAlex
Marit Stockfelt, Henri A. J. Puttonen, Ing -Marie Fyhr, Agnes Torell et autres
Objectives Giving birth to a small for gestational age (SGA) infant is a common adverse pregnancy outcome in women with SLE, but the local underlying pathogenetic mechanisms are largely unknown. We aimed to determine whether specific placental histopathological patterns of injury are …
se, fi
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Agnes Torell, Kerstin Andersson, Iva Gunnarsson, Elisabet Svenungsson et autres
OBJECTIVE: To examine B cell-activating factor (BAFF) and type I interferon (IFN) activity at the transcriptional and protein levels in blood and placental tissue in SLE compared with healthy pregnancies to assess their relationship and to determine whether BAFF levels are associated …
se, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Agnes Torell, Kerstin Andersson, Iva Gunnarsson, Elisabet Svenungsson et autres
OBJECTIVE: Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with SLE. Although disease activity and autoantibodies such as anti-Smith and anti-ribonucleoprotein associate with SGA, underlying pathological mechanisms remain unclear and reliable predictors are lacking. …
se
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Marit Stockfelt, Henri A. J. Puttonen, Ing‐Marie Fyhr, Agnes Torell et autres
Background: Giving birth to a small for gestational age (SGA) infant is a frequently occurring adverse pregnancy outcome in women with systemic lupus erythematosus (SLE) but the local pathogenetic mechanisms leading to this outcome are largely unknown. Objectives: We aimed to identify …
se, fi
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Marit Stockfelt, Agnes Torell, Iva Gunnarsson, Elisabet Svenungsson et autres
OBJECTIVES: Adverse pregnancy outcomes are more common in women with SLE compared with healthy women, but we lack prognostic biomarkers. Plasma IFN-α protein levels are elevated in a subgroup of pregnant women with SLE, but whether this is associated with pregnancy outcomes …
se, ru, cn, fr, us, hk, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg et autres
Abstract Background Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus erythematosus (SLE). We speculate whether lymphocyte subset counts are affected by pregnancy and if they relate to autoantibody profiles and/or IFNα protein in …
se, cn, fr, us, gb, no
(code pays fourni par la source)
Accès ouvert
2024
conference-paper
OpenAlex
Marit Stockfelt, Agnes Torell, Kaj Blennow, Henrik Zetterberg et autres
Objectives Adverse pregnancy outcomes (APOs) are more common among women with SLE compared to the general population and the underlying immunopathological mechanisms are largely unknown. The type I interferon (IFN) signature persists in complicated SLE pregnancies, while it is downregulated in uncomplicated …
se, us, gb, no
(code pays fourni par la source)
Accès ouvert
2024
conference-paper
OpenAlex
Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg et autres
Objective Adverse pregnancy outcomes are more common among women with systemic lupus erythematosus (SLE) compared to healthy women, but there is limited understanding on how pregnancy affects the immune system and what specific immunopathological processes that precede these complications. Lymphopenia, autoantibodies and …
se, cn, fr, us, gb, no
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg et autres
BACKGROUND: An increased risk of pregnancy complications is seen in women with systemic lupus erythematosus (SLE), but the specific immunopathological drivers are still unclear. Hallmarks of SLE are granulocyte activation, type I interferon (IFN) overproduction, and autoantibodies. Here we examined whether low-density …
se, us, gb, no
(code pays fourni par la source)
Accès ouvert
2022
conference-paper
OpenAlex
Marit Stockfelt, Agnes Torell, Gerry Larsson, Henri A. J. Puttonen et autres
Background Adverse pregnancy outcomes, including preterm birth and preeclampsia, are more prevalent in women with SLE compared to healthy women. The immunopathological mechanisms causing these complications are largely unknown and we need methods to predict which women who are at high risk …
se
(code pays fourni par la source)