Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus
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Le résumé fourni par la source
OBJECTIVES: Adverse pregnancy outcomes are more common in women with SLE compared with healthy women, but we lack prognostic biomarkers. Plasma IFN-α protein levels are elevated in a subgroup of pregnant women with SLE, but whether this is associated with pregnancy outcomes is unknown. We investigated the relationship between IFN-α, adverse pregnancy outcomes and the presence of autoantibodies in SLE pregnancy. METHODS: We followed 76 women with SLE prospectively. Protein levels of IFN-α were quantified in plasma collected in the second and third trimester with single-molecule array. Positivity for ANA and aPL antibodies was assessed during late pregnancy with multiplexed bead assay. Clinical outcomes included the adverse pregnancy outcomes small for gestational age (SGA), preterm birth and preeclampsia. RESULTS: During SLE pregnancy, women with SGA infants compared with those without had higher levels of plasma IFN-α protein, and IFN-α positivity was associated with lower birth weight of the infant. Preterm birth was associated with autoantibodies against chromatin. IFN-α protein levels associated positively with autoantibodies against chromatin, Smith/RNP (SmRNP) and RNP, but negatively with aPL antibodies. CONCLUSION: Elevated IFN-α protein in plasma of women with SLE is a potential risk factor for lower birth weight of their infants. The association between IFN-α and lower birth weight warrants further investigation regarding the pathophysiological role of IFN-α during SLE pregnancy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus
- Date Crossref
- 14/06/2024
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sahlgrenska University Hospital Rheumatology pays non établi dans la noticeÉtablissement de santé
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University of Gothenburg Department of Rheumatology and Inflammation Research pays non établi dans la noticeUniversité ou école supérieure
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Karolinska University Hospital Department of Medicine Solna pays non établi dans la noticeÉtablissement de santé
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Karolinska Institutet pays non établi dans la noticeUniversité ou école supérieure
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Lund University Department of Clinical Sciences Lund pays non établi dans la noticeUniversité ou école supérieure
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Skåne University Hospital pays non établi dans la noticeÉtablissement de santé
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Linköping University Department of Biomedical and Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Linköping University Hospital pays non établi dans la noticeÉtablissement de santé
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Uppsala University Department of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Uppsala University Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Medical Sciences pays non établi dans la noticeOrganisme public
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University of Science and Technology of China pays non établi dans la noticeUniversité ou école supérieure
Rheumatology — Sahlgrenska University Hospital, Department of Rheumatology and Inflammation Research — University of Gothenburg et Department of Medicine Solna — Karolinska University Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.