Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
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Le résumé fourni par la source
BACKGROUND: An increased risk of pregnancy complications is seen in women with systemic lupus erythematosus (SLE), but the specific immunopathological drivers are still unclear. Hallmarks of SLE are granulocyte activation, type I interferon (IFN) overproduction, and autoantibodies. Here we examined whether low-density granulocytes (LDG) and granulocyte activation increase during pregnancy, and related the results to IFNα protein levels, autoantibody profile, and gestational age at birth. METHODS: Repeated blood samples were collected during pregnancy in trimesters one, two, and three from 69 women with SLE and 27 healthy pregnant women (HC). Nineteen of the SLE women were also sampled late postpartum. LDG proportions and granulocyte activation (CD62L shedding) were measured by flow cytometry. Plasma IFNα protein concentrations were quantified by single molecule array (Simoa) immune assay. Clinical data were obtained from medical records. RESULTS: Women with SLE had higher LDG proportions and increased IFNα protein levels compared to HC throughout pregnancy, but neither LDG fractions nor IFNα levels differed during pregnancy compared to postpartum in SLE. Granulocyte activation status was higher in SLE relative to HC pregnancies, and it was increased during pregnancy compared to after pregnancy in SLE. Higher LDG proportions in SLE were associated with antiphospholipid positivity but not to IFNα protein levels. Finally, higher LDG proportions in trimester three correlated independently with lower gestational age at birth in SLE. CONCLUSION: Our results suggest that SLE pregnancy results in increased peripheral granulocyte priming, and that higher LDG proportions late in pregnancy are related to shorter pregnancy duration but not to IFNα blood levels in SLE.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
- Date Crossref
- 22/06/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Gothenburg Department of Rheumatology and Inflammation Research pays non établi dans la noticeUniversité ou école supérieure
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Sahlgrenska University Hospital Rheumatology pays non établi dans la noticeÉtablissement de santé
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University of Wisconsin–Madison pays non établi dans la noticeUniversité ou école supérieure
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UK Dementia Research Institute pays non établi dans la noticeStructure de recherche
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National Hospital for Neurology and Neurosurgery pays non établi dans la noticeÉtablissement de santé
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UCL Queen Square Institute of Neurology pays non établi dans la noticeUniversité ou école supérieure
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University College London pays non établi dans la noticeUniversité ou école supérieure
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Uppsala University Department of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Linköping University Department of Biomedical and Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Skåne University Hospital Department of Obstetrics and Gynecology pays non établi dans la noticeÉtablissement de santé
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Lund University Department of Clinical Sciences Lund pays non établi dans la noticeUniversité ou école supérieure
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Karolinska University Hospital Department of Womens and Childrens Health pays non établi dans la noticeÉtablissement de santé
Department of Rheumatology and Inflammation Research — University of Gothenburg, Rheumatology — Sahlgrenska University Hospital et University of Wisconsin–Madison, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.