High Rate of Exocrine Pancreatic Dysfunction in Pediatric Patients with Diabetes Mellitus
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Le résumé fourni par la source
OBJECTIVE: This study aimed to describe the frequency of exocrine pancreatic disease in youth with diabetes. METHODS: We conducted a retrospective chart review on data that was obtained from a single-center prospectively collected database of patients with diabetes. Patients were categorized as having type 1 diabetes, type 2 diabetes, or "Other" diabetes if they had cystic fibrosis-related diabetes, maturity-onset diabetes of the young, or drug/chemical-induced diabetes. All patients' charts were reviewed for exocrine pancreas disease, inclusive of pancreatitis or exocrine pancreatic insufficiency. RESULTS: Nine hundred eighty-eight patients with a diabetes diagnosis were included. Thirty-five out of 988 (3.5%) were diagnosed with pancreatic exocrine disease. Diabetes patients with exocrine disease compared with the ones without were significantly older (13.1 y, IQR 9.8-15.3 vs. 11.7 y, P = 0.04). Those with exocrine disease were more likely to have "Other" diabetes ( P <0.0001). The exocrine group had a lower median hemoglobin A1c at diabetes diagnosis (7%, IQR 5.8%-9.2% vs. 11.3%, 8.9%-13.8%; P <0.0001). Out of the 988 patients, 18 patients had pancreatitis diagnosed, which was 2% of the overall cohort. Nine of the 18 patients were found to have developed pancreatitis after diabetes diagnosis, or 1% of the entire diabetes cohort (9/988). CONCLUSIONS: The co-existence of exocrine and endocrine pancreatic disease occurred in 3.5% of diabetes patients. The risk of pancreatitis occurring after diabetes was 1%, a rate 100 times higher than the general pediatric population (0.01%). Future studies are needed to determine the specific mechanisms involved in the connection between endocrine and exocrine pancreatic disease in children.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- High Rate of Exocrine Pancreatic Dysfunction in Pediatric Patients with Diabetes Mellitus
- Date Crossref
- 12/08/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Cincinnati Children's Hospital Medical Center Division of Pediatric Endocrinology pays non établi dans la noticeÉtablissement de santé
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Cancer Research And Biostatistics pays non établi dans la noticeOrganisation à but non lucratif
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University of Cincinnati Medical Center pays non établi dans la noticeÉtablissement de santé
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Division of Pediatric Endocrinology pays non établi dans la noticeInstitution
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Division of Biostatistics and Epidemiology pays non établi dans la noticeInstitution
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University of Cincinnati College of Medicine Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
Division of Pediatric Endocrinology — Cincinnati Children's Hospital Medical Center, Cancer Research And Biostatistics et University of Cincinnati Medical Center, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.