Jonathan D. Burns

Raman spectroscopy and multivariate analysis for quantifying uranium(VI) under uranyl nitrate crystallization-relevant conditions

David V. Russell, Luke R. Sadergaski, Jeffrey D. Einkauf, Jennifer M. Pyles et autres

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Synthesis and Characterization of Radio-Halogenated Talazoparib Analogues for Imaging and Radioligand Therapy

Riccardo Muzzioli, Federica Pisaneschi, Seth T. Gammon, Margie N. Sutton et autres

Talazoparib (TZ) is a potent poly(ADP-ribose) polymerase 1/2 (PARP1/2) inhibitor that uniquely traps PARP complexes at sites of single-strand DNA damage thereby offering opportunities for targeted radioligand therapy. Radiolabeled halogenated TZ derivatives were synthesized using boronic ester precursors to enable incorporation of …

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Pu(IV) quantification via visible–near-infrared absorption spectroscopy: tackling interferences using D-optimal design and partial least squares

Luke R. Sadergaski, Jeffrey D. Einkauf, Sara E. Gilson, Lætitia H. Delmau et autres

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High-Yield Room-Temperature Aryl 211At Radiolabeling via Redox-Activated Column-Shipped 211At

Jehan S. Perera, Jennifer M. Pyles, Adrianna L Orsi, Christine C. Lawrence et autres

Abstract Efficient late-stage formation of aryl–211At bonds is relevant to expanding the scope of targeted α-therapy radiopharmaceuticals. In this work, a catalyst-enabled astatodeboronation approach is evaluated using wet chemically regenerated 211At recovered from shipped 3-octanone-impregnated columns. A series of aryl boronic esters …

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Uptake and Binding of At‐211 Into K‐ and Cs‐Derivatives of Alpha‐Zirconium Phosphate Nanoplatelets for Use as a Targeted Alpha Therapy Delivery Platform

B D Imansha Madhushan, Adrianna L Orsi, Jehan S. Perera, Jennifer M. Pyles et autres

The ion exchange behavior of K‐ and Cs‐derivatives of α‐zirconium phosphate, A‐ZrP, with the targeted alpha therapy (TAT) radionuclide 211 At, as At + and AtO + , has been investigated. The K‐ZrP shows strong affinity for both At + and AtO …

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Front Cover: Uptake and Binding of At‐211 Into K‐ and Cs‐Derivatives of Alpha‐Zirconium Phosphate Nanoplatelets for Use as a Targeted Alpha Therapy Delivery Platform (Small Sci. 4/2026)

B D Imansha Madhushan, Adrianna L Orsi, Jehan S. Perera, Jennifer M. Pyles et autres

Targeted Alpha Therapy Intercalation and binding of astatine-211 between the layers of alkaline-substituted alpha-zirconium phosphate nanoplatelets. Labelling these zirconium phosphate nanoplatelets with the alpha-emitting isotope astatine-211 is the first step towards providing a viable targeted alpha therapy (TAT) radiopharmaceutical. This platform also …

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Patient-Friendly Summary of the ACR Appropriateness Criteria®: Staging and Follow-up of Ovarian Cancer

Jonathan D. Burns, Saadiya Sehareen

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UV–Vis–NIR Reflectance Spectroscopy and Chemometrics for Monitoring Pu Directly on an Ion Exchange Column

Luke R. Sadergaski, Jeffrey D. Einkauf, Laetitia Helene Delmau, Jonathan D. Burns

We present a fiber-optic UV–vis–NIR reflectance spectroscopy method for direct, noninvasive monitoring of Pu(IV) in a glass ion exchange column during dynamic loading and elution in a glovebox. A movable probe enables spatially resolved spectral acquisition along the column axis, capturing distinct …

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Pu(IV) Quantification via Visible–Near-Infrared Absorption Spectroscopy: Tackling Interferences Using D-Optimal Design and Partial Least Squares

Luke R. Sadergaski, Jeffrey D. Einkauf, Sara E. Gilson, Laetitia Helene Delmau et autres

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Remote Americium Detection Using an Optical Sensor: A D-Optimal Strategy for Efficient PLS-Based Modeling

Luke R. Sadergaski, Jeffrey D. Einkauf, Jennifer M. Pyles, Laetitia Helene Delmau et autres

A fiber-optic visible–near-infrared absorption spectroscopy system in a glove box was demonstrated for remote quantification of Am(III) (0–500 µM) and HNO3 (0.1–9 M) using partial least squares regression (PLSR) models. The sensor platform, featuring a simple plug-and-play spectrophotometer, can enable noninvasive, real-time …

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Targeted Alpha Therapy Applications of Sodium-Phase Zirconium Phosphate with 225Ac

N.S.C. Becker, Imansha Madhushan, Jennifer M. Pyles, Jonathan D. Burns et autres

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Astatine-211 program at Texas A&M University

Sherry Yennello, Jonathan D. Burns, Lauren A. McIntosh, G. Tăbăcaru et autres

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