Accès ouvert
2026
article
OpenAlex
Jehan S. Perera, Jennifer M. Pyles, Adrianna L Orsi, Christine C. Lawrence et autres
Abstract Efficient late-stage formation of aryl–211At bonds is relevant to expanding the scope of targeted α-therapy radiopharmaceuticals. In this work, a catalyst-enabled astatodeboronation approach is evaluated using wet chemically regenerated 211At recovered from shipped 3-octanone-impregnated columns. A series of aryl boronic esters …
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Accès ouvert
2026
article
OpenAlex
B D Imansha Madhushan, Adrianna L Orsi, Jehan S. Perera, Jennifer M. Pyles et autres
The ion exchange behavior of K‐ and Cs‐derivatives of α‐zirconium phosphate, A‐ZrP, with the targeted alpha therapy (TAT) radionuclide 211 At, as At + and AtO + , has been investigated. The K‐ZrP shows strong affinity for both At + and AtO …
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Accès ouvert
2026
paratext
OpenAlex
B D Imansha Madhushan, Adrianna L Orsi, Jehan S. Perera, Jennifer M. Pyles et autres
Targeted Alpha Therapy Intercalation and binding of astatine-211 between the layers of alkaline-substituted alpha-zirconium phosphate nanoplatelets. Labelling these zirconium phosphate nanoplatelets with the alpha-emitting isotope astatine-211 is the first step towards providing a viable targeted alpha therapy (TAT) radiopharmaceutical. This platform also …
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Accès ouvert
2025
article
OpenAlex
Jehan S. Perera, Jennifer M. Pyles, Avinash K. Srivastava, Christine C. Lawrence et autres
The formation of a stable alkyl At–C bond occurs during the shipment of 211 At on a 3-octanone-impregnated column and the reactivity of 211 At stripped from columns has been studied. The 211 At could not be recovered from the 3-octanone organic …
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