Riccardo Muzzioli

Synthesis and Characterization of Radio-Halogenated Talazoparib Analogues for Imaging and Radioligand Therapy

Riccardo Muzzioli, Federica Pisaneschi, Seth T. Gammon, Margie N. Sutton et autres

Talazoparib (TZ) is a potent poly(ADP-ribose) polymerase 1/2 (PARP1/2) inhibitor that uniquely traps PARP complexes at sites of single-strand DNA damage thereby offering opportunities for targeted radioligand therapy. Radiolabeled halogenated TZ derivatives were synthesized using boronic ester precursors to enable incorporation of …

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Supplementary Figures S1-S28 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

28 supplementary figures supporting the main text and main figures.

Supplementary File 2 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

IP/MS summary table describing the ATGL interactome in C4-2 cells.

Supplementary Figures S1-S28 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

28 supplementary figures supporting the main text and main figures.

Supplementary File 2 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

IP/MS summary table describing the ATGL interactome in C4-2 cells.

Supplementary Tables 1-8 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

Supplementary Tables 1-8 to accompany the main text and, in particular, the materials and methods.

Data from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

Abstract Lipid metabolism plays a central role in prostate cancer. To date, the major focus has centered on de novo lipogenesis and lipid uptake in prostate cancer, but inhibitors of these processes have not benefited patients. A better understanding of how cancer …

Supplementary File 1 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

Supplementary Dataset of Phosphoproteomics Analyses of Patient Samples

Supplementary File 1 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

Supplementary Dataset of Phosphoproteomics Analyses of Patient Samples

Data from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

Abstract Lipid metabolism plays a central role in prostate cancer. To date, the major focus has centered on de novo lipogenesis and lipid uptake in prostate cancer, but inhibitors of these processes have not benefited patients. A better understanding of how cancer …

Supplementary Tables 1-8 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin et autres

Supplementary Tables 1-8 to accompany the main text and, in particular, the materials and methods.

The Interaction and Effect of a Small MitoBlock Library as Inhibitor of ALR Protein–Protein Interaction Pathway

Riccardo Muzzioli, Angelo Gallo

MIA40 and ALR of the MIA pathway mediate the import of protein precursors that form disulfides into the mitochondrial intermembrane space. This import pathway is suggested to be a linear pathway in which MIA40 first binds to the precursor via a disulfide …

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