Tomoyo Sawada

Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia

Eugenia Radulescu, Petra E. Vértes, Shizhong Han, Jennifer A. Erwin et autres

=349; sex: M/F = 242/107). Here we identify differentially connected genes (DCG) in schizophrenia networks that deviate from architectural relationships characteristic of neurotypical gene networks based on three network metrics- total connectivity (kTot), clustering coefficient (C), and intra-module degree (kIn). We find …

us, gb (code pays fourni par la source)

Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia.

Eugenia Radulescu, Petra E. Vértes, Shizhong Han, Jennifer A. Erwin et autres

Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery

Yuto Hasegawa, Hiroki Kawai, Robyn Wiseman, Gianluca Ursini et autres

INTRODUCTION: Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood. METHODS: Using aged mice, we examined the impact of abdominal surgery on cognition, glymphatic activity, and …

us (code pays fourni par la source)

SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia

Tomoyo Sawada, Arthur Sant’Anna Feltrin, Yanhong Wang, Bruno Henrique Silva Araújo et autres

Rare loss-of-function (LoF) mutations in SETD1A are associated with schizophrenia (SCZ). However, how SETD1A haploinsufficiency leads to SCZ-associated phenotypes and its relevance to patients without these rare mutations is unknown. Here, we identify SETD1A bound loci and regulated genes in human prenatal …

us, bg (code pays fourni par la source)

A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration

Laura D’Ignazio, Alan P. R. Lorenzetti, Ellen B. Penney, Taylor A. Evans et autres

A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration

Laura D’Ignazio, Alan P. R. Lorenzetti, Ellen B. Penney, Taylor A. Evans et autres

Retrotransposon activation is emerging as a significant factor in neurodegenerative disease pathogenesis. SINE-VNTR-Alu (SVAs) are hominid-specific retrotransposons that create genetic variation through insertion polymorphisms and variable short tandem repeat (STR) lengths. We investigate how the SVA (CCCTCT) n STR contributes to the …

us, au, ph (code pays fourni par la source)

Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome

Anna Bieluszewska, Phillip Wulfridge, Kuo-Chen Fang, Hong Yan et autres

Chromatin regulators are frequently mutated in autism spectrum disorders, but in most cases how they cause disease is unclear. Mutations in the activity dependent neuroprotective protein (ADNP) causes ADNP syndrome, which is characterized by intellectual deficiency and developmental delays. To identify mechanisms …

us (code pays fourni par la source)

Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive state

Ethan Tietze, Amilton de Lima Barbosa, Bruno Henrique Silva Araújo, Veronica Luiza Vale Euclydes et autres

Primary human trophoblast stem cells (TSCs) and TSCs derived from human pluripotent stem cells (hPSCs) can potentially model placental processes in vitro. Yet, the pluripotent states and factors involved in the differentiation of hPSCs to TSCs remain poorly understood. In this study, …

us, br, it (code pays fourni par la source)

Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donors’ Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia

Tomoyo Sawada, André R. Barbosa, Bruno Henrique Silva Araújo, Alejandra E. McCord et autres

OBJECTIVE: Schizophrenia is a brain disorder that originates during neurodevelopment and has complex genetic and environmental etiologies. Despite decades of clinical evidence of altered striatal function in affected patients, studies examining its cellular and molecular mechanisms in humans are limited. To explore …

us (code pays fourni par la source)

Variation in TAF1 Expression in Female Carrier-Induced Pluripotent Stem Cells and Human Brain Ontogeny Has Implications for Adult Neostriatum Vulnerability in X-Linked Dystonia Parkinsonism

Laura D’Ignazio, Ricardo S. Jacomini, Bareera Qamar, Kynon JM Benjamin et autres

Abstract X-linked dystonia-parkinsonism (XDP) is an inherited, X-linked, adult-onset movement disorder characterized by degeneration in the neostriatum. No therapeutics alter disease progression. The mechanisms underlying regional differences in degeneration and adult onset are unknown. Developing therapeutics requires a deeper understanding of how …

us (code pays fourni par la source)

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brains

Tomoyo Sawada, Amilton de Lima Barbosa, Bruno Henrique Silva Araújo, Alejandra E. McCord et autres

ABSTRACT Schizophrenia (SCZ) is a brain disorder originating during neurodevelopment with complex genetic and environmental etiologies. Despite decades of clinical evidence of altered striatal function in affected patients, its cellular and molecular underpinnings remain unclear. Here, to explore neurodevelopmental alterations in the …

us (code pays fourni par la source)

Variation in TAF1 expression in female carrier induced pluripotent stem cells and human brain ontogeny has implications for adult neostriatum vulnerability in X-linked Dystonia Parkinsonism

Laura D’Ignazio, Ricardo S. Jacomini, Bareera Qamar, Kynon JM Benjamin et autres

Abstract X-linked Dystonia-Parkinsonism (XDP) is an inherited, X-linked, adult-onset movement disorder characterized by degeneration in the neostriatum. No therapeutics alter disease progression. The mechanisms underlying regional differences in degeneration and age of onset are unknown. Developing therapeutics that target XDP-related mechanisms requires …

us (code pays fourni par la source)