Accès ouvert
2026
article
OpenAlex
Foivos Ntelemis, S. Wolf, Cher Bass, A. Geraldes et autres
Background: hybridisation (ISH) are widely used, but they are resource-intensive and time-consuming. To address these challenges, we developed PANProfiler Breast (PPB), an artificial intelligence (AI)-based digital test to analyse images of haematoxylin-eosin (H&E)-stained slides for BC biomarker assessment. Materials and methods: PPB …
sk, gb, de
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Accès ouvert
2025
article
OpenAlex
Cher Bass, Foivos Ntelemis, Julian Schmidt, Steffen Wolf et autres
Mismatch repair (MMR) deficiency occurs in 10-20% of colorectal cancer (CRC) cases, leading to microsatellite instability (MSI). Although MSI/MMR testing is critical for CRC management, high costs and long turnaround times limit testing rates and clinical utility, highlighting the need for more …
gb, us, de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
C Bordoni, Tia Z Elstow, Andrea Brancale, Richard Clarkson et autres
Amplified expression of the heat shock protein 90 (Hsp90) chaperone within cancer cells is associated with poor patient prognosis, and is known to drive tumour invasion, treatment resistance and metastasis within a range of tumour types. Several Hsp90 small molecule inhibitors have …
gb, cz
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Gilda Giancotti, Rhiannon French, Olivia Hayward, Kok Yung Lee et autres
The TNF-related apoptosis-inducing ligand (TRAIL) has potential as a therapeutic agent, as it has previously been shown to induce apoptosis in triple-negative breast cancer. However, several studies have demonstrated that patients with tumours develop resistance to TRAIL. We have previously shown that …
gb, cz
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Gilda Giancotti, Rhiannon French, Olivia Hayward, Kok Yung Lee et autres
Abstract The TNF-related apoptosis-inducing ligand (TRAIL) has potential as a therapeutic agent as it has previously been shown to induce apoptosis in triple-negative breast cancer. Recombinant human TRAIL has shown promise in pre-clinical studies of breast cancer. TRAIL exhibits specificity for triple-negative …
gb, cz
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Daniel J. Turnham, Manisha S. Mullen, Nicholas Bullock, Kathryn Gilroy et autres
As the treatment landscape for prostate cancer gradually evolves, the frequency of treatment-induced neuroendocrine prostate cancer (NEPC) and double-negative prostate cancer (DNPC) that is deficient for androgen receptor (AR) and neuroendocrine (NE) markers has increased. These prostate cancer subtypes are typically refractory …
gb, us, au
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Accès ouvert
2024
article
OpenAlex
Daniel J. Turnham, Hannah Smith, Richard Clarkson
The NF-κB co-factor Bcl3 is a proto-oncogene that promotes breast cancer proliferation, metastasis and therapeutic resistance, yet its role in breast cancer cell survival is unclear. Here, we sought to determine the effect of Bcl3 suppression alone on breast cancer cell viability, …
gb
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Accès ouvert
2024
article
OpenAlex
Gillian Seaton, Hannah Smith, Andrea Brancale, Andrew D. Westwell et autres
In the early 1990's a group of unrelated genes were identified from the sites of recurring translocations in B-cell lymphomas. Despite sharing the nomenclature 'Bcl', and an association with blood-borne cancer, these genes have unrelated functions. Of these genes, BCL2 is best …
gb, cz
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
James A. Davies, Gareth Marlow, Hanni Uusi-Kerttula, Gillian Seaton et autres
We previously developed a refined, tumor-selective adenovirus, Ad5NULL-A20, harboring tropism ablating mutations in each major capsid protein, to ablate all native means of infection. We incorporated a 20-mer peptide (A20) in the fiber knob for selective infection via αvβ6 integrin, a marker …
gb
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
James A. Davies, Gareth Marlow, Hanni Uusi-Kerttula, Gillian Seaton et autres
Background: We previously developed a refined, tumor selective adenovirus, Ad5NULL-A20, har-boring tropism ablating mutations in each major capsid protein, to ablate all native means of infection. We incorporated a 20mer peptide (A20) in the fiber knob for selective infection via αvβ6 integrin, …
gb
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Matthew Howard, Michael Jones, Richard Clarkson, Oliver Donaldson
Background: Pectoralis minor syndrome involves pain, paraesthesia and weakness in the arm due to compression of the brachial plexus passing beneath pectoralis minor; this paper reports the results of a single centre's treatment pathway in affected patients. Methods: During a four-year period, …
gb
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Łukasz Kiraga, Gabriele Cerutti, Agata Braniewska, Damian Strzemecki et autres
Proteins, as a major component of organisms, are considered the preferred biomaterials for drug delivery vehicles. Hemoglobin (Hb) has been recently rediscovered as a potential drug carrier, but its use for biomedical applications still lacks extensive investigation. To further explore the possibility …
pl, it, gb
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