Yongchun Shen

Prediction of Prolonged Length of Hospital Stay in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: An Interpretable Machine Learning Tool

Jingjing Xiong, Lian Liu, Zhenni Chen, Weiling Cai et autres

Objective: Reducing the length of hospital stay (LOS) is a core objective in the management of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). This study aimed to develop an interpretable and clinically applicable machine learning tool for predicting prolonged LOS in …

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Prevalence and clinical characteristics of sleep apnea in hypertrophic cardiomyopathy: A meta-analysis

Dongru Du, Suli Liu, Sike He, Naer An et autres

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Prognostic Value of Chest CT-Derived Pectoralis Muscle Metrics for In-Hospital Mortality and Invasive Mechanical Ventilation in AECOPD

Yating Zhang, Naer An, Zejun Liang, Jianrong He et autres

Purpose: The clinical significance of pectoralis muscle depletion during acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains unclear. This study investigated the independent prognostic value of computed tomography (CT)-derived pectoralis muscle metrics for in-hospital mortality and invasive mechanical ventilation (IMV) in …

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Targeted detection of amino acid profiles in pleural fluid and serum by liquid chromatography-tandem mass spectrometry for estimating the risks of four aetiologies of pleural effusion: a proof-of-concept study

Cheng Yan, Yi-Lu Hao, Jian-Xun Wen, Yan Niu et autres

BACKGROUND: Differentiating pleural effusion remains a challenge in clinical practice. Serum and effusion chemistries help pulmonologists assess the risk of underlying causes and select further diagnostic procedures. Amino acids (AAs) in body fluids are promising tools for estimating the probability of underlying …

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Smoking and risk of restless leg syndrome: a systematic review, meta-analysis, and Mendelian randomisation

Dongru Du, Jiangyue Qin, Xiaoju Tang, Lijuan Gao et autres

Background: Although the link between smoking and various sleep disorders has been well-established, it is still unknown whether smoking increases the risk of restless legs syndrome (RLS). We investigated this association using a meta-analysis and explored the causality through Mendelian randomisation (MR). …

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Dysfunction of mitochondria in intestinal epithelial cells: a key player in the pathogenesis of inflammatory bowel diseases

Jiangmei Pang, Mingshan Jiang, Yongbin Jia, Li Li et autres

Inflammatory bowel diseases (IBD) are a group of chronic gastrointestinal disorders with increasing incidence and prevalence that represent a major challenge for healthcare systems worldwide. Owing to their intricate and largely unknown etiologies, these patients are difficult to diagnose and treat. Intestinal …

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The relationship between the platelet/high-density lipoprotein cholesterol ratio and depressive symptoms in Chinese adults: cross-sectional and longitudinal evidence

Dongru Du, Huijuan Zhu, Xueru Hu, Yongchun Shen et autres

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Development and validation of a prediction model based on a nomogram for tuberculous pleural effusion

Suli Liu, Dongmei Wang, Lijuan Gao, Jiangyue Qin et autres

Background: Diagnosing tuberculous pleural effusion (TPE) is challenging. There is a lack of cross-sectional lateral comparisons among TPE prediction models. Objectives: We aimed to develop and validate a novel TPE prediction model and compare its diagnostic performance with that of existing models. …

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Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization

Dongru Du, Jiangyue Qin, Xueru Hu, Dan Xu et autres

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DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target

Jiangyue Qin, Ran Bi, Lian Liu, Ping Li et autres

This study aims to discover drug targeted genes and explore the potential epigenetics mechanisms in bronchiectasis. Cis-expression quantitative trait locus (eQTL) was obtained as exposure, and bronchiectasis from the FinnGen cohort was used as outcome. Mendelian Randomization (MR) was performed to identify …

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Reduced exosomal miR-215-5p activates the NEAT1/MAPK1/p-CRMP2 pathway and contributes to social dysfunction in a VPA-induced autism model

Lian Liu, Yongchun Shen, Zijian Zeng, Dan Xu et autres

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Induced Sputum Transcriptomics Profile and Serum C3 are Associated with Asthma Severity

Fawang Du, Hanchao Wang, Zhi Hong Chen, Wei Xiong et autres

Rational: Asthma severity assessment is essential for asthma management. Transcriptomics contributes substantially to asthma pathogenesis. Then, this study aimed to explore asthma severity-associated transcriptomics profile and promising biomarkers for asthma severity prediction. Methods: In discovery cohort, induced sputum cells from 3 non-severe …

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