D. Gilroy

Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis

Antoine Villa, Fiona Dewar, Walter Pisciotta, Ankit Rai et autres

PURPOSE: Humoral immunity proteins-immunoglobulins, complement proteins, and antimicrobial peptides-have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections. METHODS: We performed a systematic …

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THE SOLUBLE EPOXIDE HYDROLASE INHIBITOR GSK2256294 DECREASES LPS- INDUCED CYTOKINE MRNA EXPRESSION IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS

P Jalali, Carolyn Hyde, D. Gilroy, David Bishop‐Bailey

This study focused on a group of 49 high-yielding dairy cows (primarily Holstein Friesians) and how their interactions with wall-mounted automated brushes correlated to their mobility (also described as lameness) score (AHDB 0–3 system. Of the 49 animals in the study, 48 …

OC-009 Progression of cirrhotic liver disease towards acute-on-chronic liver failure decompensation triggers changes in innate immune cell phenotype and their response to pro-inflammatory stimuli

AA Maini, Louise China, D. Gilroy, Alison D. O’Brien

Introduction Bacterial infection is a major cause of hospital admission in liver cirrhosis and patients are highly prone to nosocomial infection. Innate immune dysfunction is implicated in these patients. As there are no current strategies to reverse immune dysfunction, antibiotics are liberally …

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OC-049 Exaggerated acute inflammation in ulcerative colitis, and promotion of its resolution by 5-aminosalicylates through anti-inflammatory hydroxy fatty acid biosynthesis

D. J. Marks, Riccardo Wysoczanski, AC Kendall, Madhur P. Motwani et autres

Introduction Acute inflammation in ulcerative colitis (UC) is protracted. Using an in vivo bacterial challenge model, we characterised the cellular and molecular determinants and consequences of the early inflammatory response in UC, and the functional impacts of 5-ASA on this process. Method …

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INFARCT SIZE IN A RAT MODEL OF ACUTE MYOCARDIAL INFARCTION IS REDUCED BY INTERLEUKIN-6 TRANS-SIGNALLING BLOCKADE USING SGP130FC BUT NOT AN ANTI-IL-6R MONOCLONAL ANTIBODY

MJ George, D Stuckey, Taylor, Aroon D. Hingorani et autres

Plasma lipid mediator (LM) profiling identifies hyper- and hypo-activated groups of patients with ACLF and targeted 20% human albumin solution infusion recalibrates abnormalities

Louise China, Arianna Maini, Romain A. Colas, Liu Ly et autres

THE RESOLUTION-PHASE MACROPHAGE

D. Gilroy

57 SECRETORY LEUKOCYTE PROTEASE INHIBITOR (SLPI) IS A PIVOTAL MEDIATOR OF ANTI-INFLAMMATORY RESPONSES IN ACUTE LIVER FAILURE

C. Antoniades, Wafa Khamri, R.D. Abeles, A. O’Brien et autres

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Macrophages in the resolution of acute inflammation

D. Gilroy

MONONUCLEAR CELLS AND THE REOSLUTION OF ACUTE INFLAMMATION

D. Gilroy

SP0135 Mononuclear cells and the reoslution of acute inflammation

D. Gilroy

gb (code pays fourni par la source)

Resolution-phase macrophages possess a unique inflammatory and bactericidal phenotype that is controlled by CAMP

Jonas Byström, Iwan R. Evans, M.J. Stables, Iqbal Toor et autres