Jing Zhao

Structure-Based Screening Identifies Polyphenol Glucuronides as Cyclophilin D Ligands

Annan Wu, Jie Zhang, Jing Zhao

(1) Background: The mitochondrial permeability transition pore (mPTP) contributes to mitochondrial dysfunction under pathological conditions. Cyclophilin D (CypD), a key regulator of sustained mPTP opening, represents an important molecular target. However, systematic strategies for selecting an appropriate CypD crystal structure for virtual …

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Circular RNA profiling revealed an evolutionarily conserved circACACA promotes liver lipid metabolism, oxidative stress, and autophagy disorder in a ceRNA manner

Jing Zhao, Shunshun Han, Jialin Xiang, Y. Chen et autres

Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized primarily by hepatocellular steatosis and lipid accumulation, which leads to hepatocyte apoptosis, autophagy, inflammation, and intracellular oxidative stress. NAFLD is recognized as one of the most prevalent and complex chronic liver diseases …

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Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis

Ruilin Pan, Yiming Zhang, Huajun Wang, Jian Guan et autres

BACKGROUND: Osteosarcoma is a primary malignant bone tumor that primarily affects adolescents and children, is highly metastatic and invasive, and has a poor survival prognosis. P3H2 is a basement membrane-associated tumor suppressor gene that is down-regulated in some types of tumors. Although …

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Evaluating the effect of protein blending on the characteristics of pea protein-based high moisture extrudates

Jie Zhang, Pengxinyi Xiao, Peng Yu, Quanhong Li et autres

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Visualized molecularly-imprinted hydrogel chips for point-of-care SERS assay of N-nitrosodiethylamine contamination in antihypertensive drugs

Fang Wang, Yimei Li, Jing Zhao, Jing Ye

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Molecular sieving meets ion exchange: KCoFC@UiO-66 as a multi-functional adsorbent for high-efficiency rubidium recovery from lithium tailing leachate

Chuan Peng, Jing Zhao, Jin Huang, Yongge Yao et autres

Rubidium (Rb), a critical strategic metal with extensive applications in energy storage, electronics, and nuclear medicine, faces extraction challenges due to its low natural abundance and dispersed occurrence. To address the inefficiency and selectivity limitations of conventional extraction methods, this study synthesized …

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A highly branched RG-I pectin from zucchini and its effects on the intestinal microecology based on a honeybee model

Yuanxue Jiang, Xunze Han, Yu Zhang, Yunlu Wei et autres

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Volatiles from non-host plant Baccaurea ramiflora (Malpighiales: Phyllanthaceae) attract cowpea thrips, Megalurothrips usitatus (Thysanoptera: Thripidae)

Haiyan Qiu, Jing Zhao, Dongyin Han, Yueguan Fu et autres

The cowpea thrips Megalurothrips usitatus (Bagnall) (Thysanoptera: Thripidae) exhibited unexpected aggregation on flowers of the non-host Baccaurea ramiflora Lour. (Malpighiales: Phyllanthaceae), suggesting floral volatile-mediated attraction. We systematically investigated this phenomenon through: (i) GC-MS identification of B. ramiflora floral volatiles; (ii) electroantennographic (EAG) …

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Destruction of sludge floc and extracellular polymeric substances structure by natural deep eutectic solvent with thermal treatment assistant for synergistic promotion of dewaterability and protein recovery from waste-activated sludge

Xinlin Chen, Jin Huang, Jing Zhao, Xuejiao Hu et autres

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Effect of the degree of methyl esterification on the physicochemical properties and hypoglycaemic potential of pectin

Xu Jiao, Bingjie Yang, Fei Li, Luyao Zhang et autres

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Freeze-thaw damage characteristics and discrete element simulation analysis of composite fibers asphalt mixture

Xu Li, F Wang, Haonan Yu, Hanjun Li et autres

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Seminal plasma exosome derived miR-26-5p can regulate decidual macrophage polarization via PTEN / PI3K / AKT signaling pathway

Yan Zhang, Xiaolin Chen, Jie Li, Xin Chen et autres

The immunomodulatory effects of seminal plasma (SP) on the maternal immune system play an important role in the implantation and development of the embryo. Decidual macrophages (dMΦs) are one of the major immune cells in the maternal-fetal immune microenvironment, and their M2-type …

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