Elgar Oswald

First-Line Administration of Fibrinogen Concentrate in the Bleeding Trauma Patient: Searching for Effective Dosages and Optimal Post-Treatment Levels Limiting Massive Transfusion—Further Results of the RETIC Study

Nicole Innerhofer, Benjamin Treichl, Christopher Rugg, D Friès et autres

Fibrinogen supplementation is recommended for treatment of severe trauma hemorrhage. However, required dosages and aimed for post-treatment fibrinogen levels remain a matter of discussion. Within the published RETIC study, adult patients suffering trauma-induced coagulopathy were randomly assigned to receive fibrinogen concentrate (FC) …

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Difficult reversal of dabigatran with idarucizumab in a multiple-trauma patient: A question of dose?

Mathias Ströhle, Christopher Rugg, Stefan Schmid, D Friès et autres

Dabigatran is an oral anticoagulant directly acting as thrombin inhibitor. The monoclonal antibody idarucizumab was developed to reverse its anticoagulatory effects after application of a standardized dose. Following administration, dabigatran plasma level rebounds have been reported but its consequences are not fully …

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A randomized trial comparing the Ambu® Aura-i™ and the Ambu® Aura Gain™ laryngeal mask as conduit for tracheal intubation in children

Lukas Gasteiger, Elgar Oswald, M. Keplinger, Gabriel Putzer et autres

BACKGROUND: The Ambu Aura Gain is a newer second-generation supraglottic airway device designed for fibreoptic bronchoscopy (FOB)-guided tracheal intubation. METHODS: 57 patients between 18 months and six years of age were randomized to receive either the Ambu Aura-I (N.=29) or the Ambu …

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Efficacy of prehospital administration of fibrinogen concentrate in trauma patients bleeding or presumed to bleed (FIinTIC)

Bernhard Ziegler, Mirjam Bachler, H Haberfellner, Christian Niederwanger et autres

BACKGROUND: Trauma-induced coagulopathy (TIC) substantially contributes to mortality in bleeding trauma patients. OBJECTIVE: The aim of the study was to administer fibrinogen concentrate in the prehospital setting to improve blood clot stability in trauma patients bleeding or presumed to bleed. DESIGN: A …

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Dynamics of Platelet Counts in Major Trauma: The Impact of Haemostatic Resuscitation and Effects of Platelet Transfusion—A Sub-Study of the Randomized Controlled RETIC Trial

Helmuth Tauber, Nicole Innerhofer, Daniel von Langen, Mathias Ströhle et autres

Although platelets play a central role in haemostasis, the dynamics of platelet counts during haemostatic resuscitation, the response to platelet transfusion, and effects on clinical outcome are poorly described for trauma patients. As a sub-study of the already published randomized controlled RETIC …

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A Prospective Pilot Trial to Assess the Efficacy of Argatroban (Argatra®) in Critically Ill Patients with Heparin Resistance †

Mirjam Bachler, Tobias Hell, Johannes Bösch, Benedikt Treml et autres

The current study aims to evaluate whether prophylactic anticoagulation using argatroban or an increased dose of unfractionated heparin (UFH) is effective in achieving the targeted activated partial thromboplastin time (aPTT) of more than 45 s in critically ill heparin-resistant (HR) patients. Patients …

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Efficacy of Pre-Hospital Administration of Fibrinogen Concentrate (Clottafact®) in Trauma Patients Presumed to Bleed (FIinTIC): Results from a Multicentre Double-Blind, Placebo-Controlled, Randomised, Pilot Trial

Bernhard Ziegler, Mirjam Bachler, H Haberfellner, Petra Innerhofer et autres

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Reversing anticoagulation in the hemorrhaging patient

Benedikt Treml, Elgar Oswald, Bettina Schenk

PURPOSE OF REVIEW: Anticoagulants in general, but especially the relatively new direct oral anticoagulants and platelet inhibitors, pose a great challenge for physicians in the hemorrhaging patient. The aim of the present review is to provide an overview on recent studies dealing …

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A comparison of the new ROTEM ® sigma with its predecessor, the ROTEM delta

Bettina Schenk, Klaus Görlinger, Benedikt Treml, Helmuth Tauber et autres

Summary Thromboelastometry point‐of‐care coagulation testing facilitates optimised management of bleeding. Previous thromboelastometry systems required the blood sample and liquid reagents to be pipetted in several manual steps by trained personnel. The ROTEM sigma coagulation analyser is a fully automated point‐of‐care device. We …

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Early fibrinogen-concentrate administration in management of trauma-induced coagulopathy – Authors' reply

Petra Innerhofer, D Friès, Elgar Oswald

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Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial

Petra Innerhofer, D Friès, Markus Mittermayr, Nicole Innerhofer et autres

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Efficacy of Argatroban in Critically Ill Patients with Heparin Resistance: A Retrospective Analysis

Benjamin Treichl, Mirjam Bachler, Ingo Lorenz, Barbara Friesenecker et autres

The patients who do not respond even to very high dosages of heparin are assumed to suffer from heparin resistance. The aim of this study was to investigate whether critically ill patients suffering from heparin resistance generally have low antithrombin III (AT) …

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